Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Immunology >> Innate Immunity >> Macrophage / Inflamm.
Overview
Product name
Anti-TLR9 antibody
See all TLR9 products (15) ...
Description
Rabbit polyclonal to TLR9
Tested applications
IHC-FoFr, WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Human
Immunogen
Synthetic peptide corresponding to 16 amino acids near to the C terminus of the protein (Human).
Positive control
Mouse spleen cells and cell lysate .
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
Imunoaffinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> TLR Signaling
Signal Transduction >> Adapters >> Transmembrane
Immunology >> Immunoglobulins >> Receptors
Immunology >> Innate Immunity >> Macrophage / Inflamm.
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TLR9 antibody (ab37154)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab37154 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-FoFr: Use at an assay dependent concentration. (PubMed: 21549006)
WB: Use a concentration of 1 - 2 µg/ml.Detects a band of approximately 95 kDa.
IHC-P: Use a concentration of 2 µg/ml
Target
Function
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific of microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.
Tissue specificity
Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre-dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver.
Sequence similarities
Belongs to the Toll-like receptor family.
Contains 26 LRR (leucine-rich) repeats.
Contains 1 TIR domain.
Cellular localization
Endoplasmic reticulum membrane. Endosome. Lysosome. Cytoplasmic vesicle > phagosome. Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
Target information above from: UniProt accessionQ9NR96
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 289 antibody
- CD289 antibody
- TLR 9 antibody
see all
Database links
- Entrez Gene: 54106 Human
- Entrez Gene: 81897 Mouse
- Omim: 605474 Human
- SwissProt: Q9NR96 Human
- SwissProt: Q9EQU3 Mouse
- Unigene: 87968 Human
- Unigene: 44889 Mouse
Anti-TLR9 antibody images:
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TLR9 antibody (ab37154)
ab37154 at 2 µg/ml staining TLR9 in mouse spleen cells by IHC.
References for Anti-TLR9 antibody (ab37154)
This product has been referenced in:
- Hua Fet al. Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone. J Neuroinflammation 8:42 (2011). WB, IHC-FoFr; Mouse.Read more (PubMed: 21549006) »
See 1 publication for this product
Publishing research using ab37154? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"