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TMCB

Product code: ab120289 (formerly Asc-289)

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Overview

Product name

TMCB

Description

Selective CK2 inhibitor

Biological description

CK2 inhibitor (Ki = 0.25 μM), more selective than DMAT. Unlike DMAT, TMCB displays selectivity over PIM1, HIPK2 and DYRK1a (Ki values are 8.65, 15.25 and 11.90 μM respectively) and a more favourable selectivity profile over a range of other kinases.

Purity

> 98%

General notes

Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Properties

Chemical name

2-(4,5,6,7-Tetrabromo-2-(dimethylamino)-1H-benzo[d]imidazol-1-yl)acetic acid

Molecular Weight

534.82

Chemical structure

Chemical Structure

Molecular formula

C11H9Br4N3O2

CAS Number

905105-89-7

Solubility

Soluble in DMSO

Storage instructions

Store at room temperature.

Research areas

Biochemicals >> Pharmacology >> Enzymes >> Kinase >> Casein kinase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals

References for TMCB (ab120289)

This product has been referenced in:

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"