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Products:Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
Overview
Product name
Anti-TMPRSS2 antibody - Aminoterminal end
See all TMPRSS2 products (6) ...
Description
Rabbit polyclonal to TMPRSS2 - Aminoterminal end
Specificity
This antibody recognizes the 492 and 489 amino acid forms of TMPRSS2, and the 119 amino acid form if it is expressed. It does not react with the other TMPRSSs. We have a range of domain specific antibodies for this target. For a full list please see all TMPRSS2 antibodies.
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide (Human) based on the aminoterminal end (within the first 80 N-terminal amino acids)
Positive control
mouse stomach tissue lysate and DU145, DUC26, or SW620 cell lysates
Properties
Form
Liquid
Storage instructions
Store at -20°C. Stable for 12 months at -20°C
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 500mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Enzymes >> Other
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> TMPRSS
Neuroscience >> Neurology process >> Neurodegenerative disease >> Other
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Western blot - TMPRSS2 antibody - Aminoterminal end (ab56110)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56110 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000 - 1/5000.Predicted molecular weight: 54 kDa.
Target
Tissue specificity
Expressed strongly in small intestine. Also expressed in prostate, colon, stomach and salivary gland.
Sequence similarities
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain.
Cellular localization
Cell membrane and Secreted. Activated by cleavage and secreted.
Target information above from: UniProt accessionO15393
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Transmembrane protease, serine 2, EC 3.4.219 antibody
- D16Ertd61e antibody
- Epitheliasin antibody
see all
Database links
- Entrez Gene: 7113 Human
- Omim: 602060 Human
- SwissProt: O15393 Human
- Unigene: 439309 Human
Anti-TMPRSS2 antibody - Aminoterminal end images:
Western blot - TMPRSS2 antibody - Aminoterminal end (ab56110)
All lanes : Anti-TMPRSS2 antibody - Aminoterminal end (ab56110) at 1/1000 dilution
Lane 1 : Mouse Stomach Lystae
Lane 2 : Mouse Stomach Lystae
Lane 3 : DUC26 Cell Lysate
Lane 4 : DUC26 Cell Lysate
Lane 5 : DUC26 Cell Lysate
Lane 6 : HEK293 Cell Lysate
Lane 7 : HEK293 Cell Lysate
Predicted band size : 54 kDa
References for Anti-TMPRSS2 antibody - Aminoterminal end (ab56110)
This product has been referenced in:
- Matsuyama Set al. Efficient activation of the severe acute respiratory syndrome coronavirus spike protein by the transmembrane protease TMPRSS2. J Virol 84:12658-64 (2010). IHC-P, IF; Cynomolgus Monkey.Read more (PubMed: 20926566) »
- Shirogane Yet al. Efficient multiplication of human metapneumovirus in Vero cells expressing the transmembrane serine protease TMPRSS2. J Virol 82:8942-6 (2008). WB; Human.Read more (PubMed: 18562527) »
See all 2 publications for this product
Publishing research using ab56110? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"