Anti-TMPRSS4 antibody (ab188816)
Key features and details
- Rabbit polyclonal to TMPRSS4
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-TMPRSS4 antibody
See all TMPRSS4 primary antibodies -
Description
Rabbit polyclonal to TMPRSS4 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Horse, Dog, Pig, Chimpanzee, Monkey, Gorilla, Common marmoset, Orangutan -
Immunogen
Synthetic peptide corresponding to Human TMPRSS4 (internal sequence). 19 amino acids long.
Database link: Q9NRS4 -
Positive control
- Human pancreatic carcinoma, human pancreas tissue.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
-
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab188816 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P |
Use a concentration of 15 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
|
Notes |
---|
IHC-P
Use a concentration of 15 - 20 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. |
Target
-
Function
Probable protease. Seems to be capable of activating ENaC. -
Tissue specificity
High levels in pancreatic, gastric, colorectal and ampullary cancer. Very weak expression in normal gastrointestinal and urogenital tract. -
Sequence similarities
Belongs to the peptidase S1 family.
Contains 1 LDL-receptor class A domain.
Contains 1 peptidase S1 domain.
Contains 1 SRCR domain. -
Cellular localization
Membrane. - Information by UniProt
-
Database links
- Entrez Gene: 451581 Chimpanzee
- Entrez Gene: 100390415 Common marmoset
- Entrez Gene: 489387 Dog
- Entrez Gene: 101147411 Gorilla
- Entrez Gene: 100071190 Horse
- Entrez Gene: 56649 Human
- Entrez Gene: 100436934 Orangutan
- Entrez Gene: 100514419 Pig
see all -
Alternative names
- UNQ776/PRO1570 antibody
- CAPH2 antibody
- Channel-activating protease 2 antibody
see all
Images
Datasheets and documents
-
SDS download
-
Datasheet download
References (3)
ab188816 has been referenced in 3 publications.
- Kerslake R et al. Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs. Mol Med Rep 25:N/A (2022). PubMed: 35211765
- Wang C et al. Novel Potential Biomarkers Associated With Epithelial to Mesenchymal Transition and Bladder Cancer Prognosis Identified by Integrated Bioinformatic Analysis. Front Oncol 10:931 (2020). PubMed: 32695668
- Fan X et al. The upregulation of TMPRSS4, partly ascribed to the downregulation of miR-125a-5p, promotes the growth of human lung adenocarcinoma via the NF-?B signaling pathway. Int J Oncol 53:148-158 (2018). PubMed: 29750426