Anti-TNF Receptor I antibody [H398] (ab2257)
- Product nameAnti-TNF Receptor I antibody [H398]See all TNF Receptor I primary antibodies ...
- DescriptionMouse monoclonal [H398] to TNF Receptor I
- Specificityab2257 reacts with the extra-cellular part of the TNF-RI. It also reacts with the soluble receptor. Be aware that the antibody competes with TNF-alpha.
- Tested applicationsIP, IHC-Fr, Flow Cyt more details
- Species reactivityReacts with: Human
- Positive control
- Frozen sections: Human lymphnodes. Flow cytometry: HeLa cells. Please note: HeLa cells can differ strongly in TNF-R numbers with some populations having very low numbers.
- General notes
The reactivity of ab2257 with cellbound TNF-Receptor is minimally inhibited by high concentrations of TNF-alpha.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPBS with 0.02% sodium azide
- Concentration information loading...
- PurityIgG fraction
- Primary antibody notes The reactivity of ab2257 with cellbound TNF-Receptor is minimally inhibited by high concentrations of TNF-alpha.
- Clonality Monoclonal
- Clone numberH398
- Light chain typeunknown
Our Abpromise guarantee covers the use of ab2257 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IP: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Involvement in diseaseFamilial hibernian fever
Multiple sclerosis 5
- Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
modificationsThe soluble form is produced from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
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References for Anti-TNF Receptor I antibody [H398] (ab2257)
This product has been referenced in:
- Greco SJ & Rameshwar P Enhancing effect of IL-1alpha on neurogenesis from adult human mesenchymal stem cells: implication for inflammatory mediators in regenerative medicine. J Immunol 179:3342-50 (2007). WB ; Human . Read more (PubMed: 17709551) »
- Grell M et al. TR60 and TR80 tumor necrosis factor (TNF)-receptors can independently mediate cytolysis. Lymphokine Cytokine Res 12:143-8 (1993). Read more (PubMed: 8394147) »