Anti-TNF Receptor I antibody [MR1-2] (ab8160)
- Product nameAnti-TNF Receptor I antibody [MR1-2]See all TNF Receptor I primary antibodies ...
- DescriptionMouse monoclonal [MR1-2] to TNF Receptor I
- SpecificityThe antibody reacts with the extra-cellular part of the TNF-RI. It also reacts with the soluble receptor. TNF-RI is present on most cell types and is considered to play a prominent role in cell stimulation by TNF-alpha: Induction of cytotoxicity and other functions are mediated largely via TNF-RI. The antibody crossreacts with rhesus and cynomolgus natural TNF-RI.
- Tested applicationsIP, IHC-Fr more details
- Species reactivityReacts with: Human
- Positive control
- Frozen sections: Human lymphnodes
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
- Storage bufferPBS with 0.02% sodium azide
- Concentration information loading...
- PurityIgG fraction
- Clonality Monoclonal
- Clone numberMR1-2
Our Abpromise guarantee covers the use of ab8160 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
The antibody is an agonistic antibody useful for cell culture experiments and histology on frozen sections.
Furthermore it can be used for immunoprecipitation.
The reactivity of the antibody with cellbound TNF-Receptor is minimally inhibited by high concentrations of TNF-alpha.
Working dilution for frozen sections is 1:10 - 1:20.
- FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Involvement in diseaseFamilial hibernian fever
Multiple sclerosis 5
- Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
modificationsThe soluble form is produced from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
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References for Anti-TNF Receptor I antibody [MR1-2] (ab8160)
ab8160 has not yet been referenced specifically in any publications.