Anti-TNF Receptor I antibody (ab58436)
- Product nameAnti-TNF Receptor I antibodySee all TNF Receptor I primary antibodies ...
- DescriptionRabbit polyclonal to TNF Receptor I
- Specificityab58436 detects endogenous levels of total TNF Receptor I protein. This antibody binds to the C-terminal cytoplasmic domain and reacts with three isoforms (1, 2, and 3) of human TNF Receptor I.
- Tested applicationsELISA, IHC-P more details
- Species reactivityReacts with: Mouse, Rat, Human
Synthetic peptide derived from an internal sequence of human TNF Receptor I
- Positive control
- IHC-P: Human breast carcinoma.
- Storage instructionsStore at -20°C. Stable for 12 months at -20°C
- Storage bufferPreservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesab58436 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab58436 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||IHC-P: Use at an assay dependent dilution.|
- FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Involvement in diseaseFamilial hibernian fever
Multiple sclerosis 5
- Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
modificationsThe soluble form is produced from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
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Anti-TNF Receptor I antibody images
ab58436, at 1/50 dilution, staining TNF Receptor I in paraffin embedded human breast carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.
References for Anti-TNF Receptor I antibody (ab58436)
This product has been referenced in:
- K_M_Coxon, J_Duggan, S_Nizari, L_Guo, M_F_Cordeiro Effects of Ocular Hypertension on Tumor Necrosis (TNF) Receptors and RGC Apoptosis ARVO Meeting Abstracts 51: (2010). Read more (PubMed: ) »
- Moutsopoulos NM et al. Lack of efficacy of etanercept in Sjögren syndrome correlates with failed suppression of tumour necrosis factor alpha and systemic immune activation. Ann Rheum Dis 67:1437-43 (2008). IHC-P ; Human . Read more (PubMed: 18198195) »