Anti-TNF Receptor I antibody (ab58436)

Overview

• Product nameAnti-TNF Receptor I antibodySee all TNF Receptor I primary antibodies ...
• Description
  Rabbit polyclonal to TNF Receptor I
• Specificityab58436 detects endogenous levels of total TNF Receptor I protein. This antibody binds to the C-terminal cytoplasmic domain and reacts with three isoforms (1, 2, and 3) of human TNF Receptor I.
• Tested applicationsELISA, IHC-P more details
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide derived from an internal sequence of human TNF Receptor I

• Positive controlIHC-P: Human breast carcinoma.

Properties

• FormLiquid
• Storage instructionsStore at -20°C. Stable for 12 months at -20°C
• Storage bufferPreservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesab58436 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Stem Cells
  • Mesenchymal Stem Cells
  • Surface Molecules

  • Cancer
  • Invasion/microenvironment
  • Angiogenesis
  • Angiogenic growth factors

  • Cancer
  • Growth factors
  • TNF

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Cardiovascular
  • Atherosclerosis
  • Vascular Inflammation
  • Inflammatory mediators

  • Cardiovascular
  • Angiogenesis
  • Angiogenic Factors

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

Applications

Target

• FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
• Involvement in diseaseFamilial hibernian fever (FHF) [MIM:142680]: A hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases. Note=The disease is caused by mutations affecting the gene represented in this entry.
  Multiple sclerosis 5 (MS5) [MIM:614810]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. An intronic mutation affecting alternative splicing and skipping of exon 6 directs increased expression of isoform 4 a transcript encoding a C-terminally truncated protein which is secreted and may function as a TNF antagonist.
• Sequence similaritiesContains 1 death domain.
  Contains 4 TNFR-Cys repeats.
• DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
  Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
• Post-translational
  modificationsThe soluble form is produced from the membrane form by proteolytic processing.
• Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.

Target information above from: UniProt accession P19438 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7132 Human
  • Entrez Gene: 21937 Mouse
  • Entrez Gene: 25625 Rat
  • Omim: 191190 Human
  • SwissProt: P19438 Human
  • SwissProt: P25118 Mouse
  • SwissProt: P22934 Rat
  • Unigene: 279594 Human

  • Unigene: 11119 Rat

  see all

• Alternative names
  CD120a antibodyCD120a antigen antibodyFPF antibody

  MGC19588 antibodyp55 antibodyp55 R antibodyp55-R antibodyp55R antibodyp60 antibodyTBP1 antibodyTBPI antibodyTNF R antibodyTNF R I antibodyTNF R1 antibodyTNF R55 antibodyTNF-R1 antibodyTNF-RI antibodyTNFAR antibodyTNFR 1 antibodyTNFR I antibodyTNFR-I antibodyTNFR1 antibodyTNFR55 antibodyTNFR60 antibodyTNFRI antibodyTNFRSF1a antibodyTNR1A_HUMAN antibodyTumor necrosis factor alpha receptor antibodyTumor necrosis factor binding protein 1 antibodyTumor necrosis factor receptor 1 antibodyTumor necrosis factor receptor superfamily member 1A antibodyTumor necrosis factor receptor superfamily, member 1A antibodyTumor necrosis factor receptor type 1 antibodyTumor necrosis factor receptor type I antibodyTumor necrosis factor-binding protein 1 antibody

  see all

Anti-TNF Receptor I antibody images

• 

  Immunohistochemistry (Paraffin-embedded sections) - TNF Receptor I antibody (ab58436)
  ab58436, at 1/50 dilution, staining TNF Receptor I in paraffin embedded human breast carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.