Anti-TNF Receptor I antibody (ab7630)
- Product nameAnti-TNF Receptor I antibodySee all TNF Receptor I primary antibodies ...
- DescriptionRabbit polyclonal to TNF Receptor I
- SpecificityDoes not recognize human sTNFRp75. In ELISA formats and other immunoreactive assays, this antibody will detect the extracellular domain of the TNFRp55 found in human body fluids, particularly in the circulation, urine and supernatants of cells and synovial fluid. This antibody can be used for FACS analysis. Caution should be exhibited as the F(c) domain of the rabbit IgG molecule may interact with cells non-specifically.
- Tested applicationsDot Blot, ELISA, Flow Cyt, IP, RIA, WB more details
- Species reactivityReacts with: Rabbit
Recombinant human sTNFRp55 expressed in Chinese Hamster Cells.
- EpitopeExtracellular domain of the cell bound human TNFRp55
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Sodium Azide
Constituents: 0.15M Sodium Chloride, 0.02M Potassium Phosphate. pH 7.2
- Concentration information loading...
- PurityIgG fraction
- Purification notesThis is an IgG preparation of whole rabbit serum purified by Protein G chromatography.
- Clonality Polyclonal
Our Abpromise guarantee covers the use of ab7630 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA: 1/2000 - 1/8000 (against soluble extracellular sTNFRp55 using goat anti-rabbit HRP, ab6721).
Flow Cyt: Use at an assay dependant dilution.
IP: 1/400 - 1/800.
WB: 1/200 - 1/400 using goat anti-rabbit (HRP) ab6721.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Involvement in diseaseFamilial hibernian fever (FHF) [MIM:142680]: A hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases. Note=The disease is caused by mutations affecting the gene represented in this entry.
Multiple sclerosis 5 (MS5) [MIM:614810]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. An intronic mutation affecting alternative splicing and skipping of exon 6 directs increased expression of isoform 4 a transcript encoding a C-terminally truncated protein which is secreted and may function as a TNF antagonist.
- Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
modificationsThe soluble form is produced from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
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References for Anti-TNF Receptor I antibody (ab7630)
ab7630 has not yet been referenced specifically in any publications.