Anti-TNF Receptor I antibody (ab7743)

Overview

  • Product nameAnti-TNF Receptor I antibodySee all TNF Receptor I primary antibodies ...
  • Description
    Rabbit polyclonal to TNF Receptor I
  • SpecificityThe antibody reacts with the extra-cellular part of the TNF-R I and with the soluble receptor.
  • Tested applicationsIP, WB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant human tumour necrosis factor receptor type 1

Properties

Applications

Our Abpromise guarantee covers the use of ab7743 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IP
WB
  • Application notesThe antibody is an agonistic antibody useful for detection of TNF-R I. It can be used for Western blotting and immunoprecipitation. The reactivity of the antibodies with soluble TNF-Receptor is not inhibited by high concentrations of TNF-a.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
    • Involvement in diseaseFamilial hibernian fever
      Multiple sclerosis 5
    • Sequence similaritiesContains 1 death domain.
      Contains 4 TNFR-Cys repeats.
    • DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
      Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
    • Post-translational
      modifications
      The soluble form is produced from the membrane form by proteolytic processing.
    • Cellular localizationCell membrane. Golgi apparatus membrane. Secreted. A secreted form is produced through proteolytic processing and Secreted. Lacks a Golgi-retention motif, is not membrane bound and therefore is secreted.
    • Target information above from: UniProt accession P19438 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
    • Alternative names
      • CD120a antibody
      • CD120a antigen antibody
      • FPF antibody
      • MGC19588 antibody
      • p55 antibody
      • p55 R antibody
      • p55-R antibody
      • p55R antibody
      • p60 antibody
      • TBP1 antibody
      • TBPI antibody
      • TNF R antibody
      • TNF R I antibody
      • TNF R1 antibody
      • TNF R55 antibody
      • TNF-R1 antibody
      • TNF-RI antibody
      • TNFAR antibody
      • TNFR 1 antibody
      • TNFR I antibody
      • TNFR-I antibody
      • TNFR1 antibody
      • TNFR55 antibody
      • TNFR60 antibody
      • TNFRI antibody
      • TNFRSF1a antibody
      • TNFRSF1a antibody
      • TNR1A_HUMAN antibody
      • Tumor necrosis factor alpha receptor antibody
      • Tumor necrosis factor binding protein 1 antibody
      • Tumor necrosis factor receptor 1 antibody
      • Tumor necrosis factor receptor superfamily, member 1A antibody
      • Tumor necrosis factor receptor type 1 antibody
      • Tumor necrosis factor receptor type I antibody
      • Tumor necrosis factor-binding protein 1 antibody
      see all

    References for Anti-TNF Receptor I antibody (ab7743)

    ab7743 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your email and I'm sorry to hear that you are experiencing difficulty with these two antibodies. For ab15563, it is suggested on the online datasheet to use thymus as a positive control. Also, TNF receptors are present on nearly all cell ...

    Read More

    We suggest using ab7360 at 1/400 - 1/800. Pre-clearing with a non-specific rabbit IgG is helpful to reduce background. We are not aware of any references for the use of this antibody in IP.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"