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Overview

  • Product nameAnti-TNF Receptor II antibody [80M2]See all TNF Receptor II primary antibodies ...
  • Description
    Mouse monoclonal [80M2] to TNF Receptor II
  • SpecificityThe antibody reacts with the extracellular part of the TNF RII, it also reacts with the soluble receptor.
  • Tested applicationsWB, IHC-Fr, Flow Cyt, IP more details
  • Species reactivity
    Reacts with: Rat, Human

    Does not react with

    Mouse
  • Immunogen

    This information is considered to be commercially sensitive

  • Positive controlHuman lymph nodes (immunohistochemistry) or PHA activated T cells (flow cytometry).

Properties

Applications

Our Abpromise guarantee covers the use of ab17038 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
IHC-Fr IHC-Fr: Use at an assay dependent dilution.
Flow Cyt Flow Cyt: Use at an assay dependent dilution.
IP IP: Use at an assay dependent dilution.

Target

  • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Post-translational
    modifications    Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P20333 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CD 120b antibodyCD120b antibodyCD120b antigen antibody
        Etanercept antibodyp75 antibodyp75TNFR antibodyp80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodyTBP-2 antibodyTBP2 antibodyTBPII antibodyTNF R II antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFBR antibodyTNFR 2 antibodyTNFR-II antibodyTNFR2 antibodyTNFR75 antibodyTNFR80 antibodyTNFRII antibodyTNFRSF 1B antibodyTNFRSF1B antibodyTNR1B antibodyTNR1B_HUMAN antibodyTumor necrosis factor beta receptor antibodyTumor necrosis factor binding protein 2 antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor superfamily member 1B precursor antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
      see all

    References for Anti-TNF Receptor II antibody [80M2] (ab17038)

    This product has been referenced in:
    • Stellwagen D  et al. Differential regulation of AMPA receptor and GABA receptor trafficking by tumor necrosis factor-alpha. J Neurosci 25:3219-28 (2005). Read more (PubMed: 15788779) »

    See 1 Publication for this product

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