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Overview

  • Product nameAnti-TNF Receptor II antibody [HM102] (FITC)See all TNF Receptor II primary antibodies ...
  • Description
    Rat monoclonal [HM102] to TNF Receptor II (FITC)
  • ConjugationFITC
  • Tested applicationsELISA, IHC-Fr, Flow Cyt more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Recombinant protein fragment, corresponding to the extra cellular part of Mouse TNF Receptor II

Properties

Applications

Our Abpromise guarantee covers the use of ab81672 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ELISA ELISA: Use at an assay dependent dilution.
IHC-Fr IHC-Fr: 1/50.
Flow Cyt Flow Cyt: 1/50.

Target

  • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Post-translational
    modifications    Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P20333 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CD120b antibodyp75 antibodyp75TNFR antibody
        p80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodyTBP-2 antibodyTBPII antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFR-II antibodyTNFR80 antibodyTNFRII antibodyTNFRSF1B antibodyTNR1B_HUMAN antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
      see all

    References for Anti-TNF Receptor II antibody [HM102] (FITC) (ab81672)

    This product has been referenced in:
    • Chee J  et al. TNF Receptor 1 Deficiency Increases Regulatory T Cell Function in Nonobese Diabetic Mice. J Immunol 187:1702-12 (2011). Flow Cyt ; Mouse . Read more (PubMed: 21734073) »

    See 1 Publication for this product

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