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Overview

  • Product nameAnti-TNF Receptor II antibody [HM102]See all TNF Receptor II primary antibodies ...
  • Description
    Rat monoclonal [HM102] to TNF Receptor II
  • SpecificityMouse TNF-R II and the soluble receptor.
  • Tested applicationsIP, IHC-Fr, Flow Cyt more details
  • Species reactivity
    Reacts with: Mouse
  • EpitopeExtra-cellular part of the receptor.

Properties

Applications

Our Abpromise guarantee covers the use of ab7369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IP
IHC-Fr
Flow Cyt
  • Application notesThe antibody is an agonistic antibody useful for cell culture experiments and for detection of TNF-R II by FACS analysis.
    Furthermore it can be used for immunoprecipitation and histology on frozen sections.
    The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-?.

    • Target

    • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    • Sequence similaritiesContains 4 TNFR-Cys repeats.
    • Post-translational
      modifications      Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
      A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
    • Cellular localizationSecreted and Cell membrane.

      • Target information above from: UniProt accession P20333 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          CD 120b antibodyCD120b antibodyCD120b antigen antibody
          Etanercept antibodyp75 antibodyp75TNFR antibodyp80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodyTBP-2 antibodyTBP2 antibodyTBPII antibodyTNF R II antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFBR antibodyTNFR 2 antibodyTNFR-II antibodyTNFR2 antibodyTNFR75 antibodyTNFR80 antibodyTNFRII antibodyTNFRSF 1B antibodyTNFRSF1B antibodyTNR1B antibodyTNR1B_HUMAN antibodyTumor necrosis factor beta receptor antibodyTumor necrosis factor binding protein 2 antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor superfamily member 1B precursor antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
        see all

      References for Anti-TNF Receptor II antibody [HM102] (ab7369)

      This product has been referenced in:
      • Tesz GJ  et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . Read more (PubMed: 17500068) »

      See 1 Publication for this product

      Publishing research using ab7369 ? Please let us know so that we can cite the reference in this datasheet

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      Submit an Abreview for ab7369 Submit a Question for ab7369

      Displaying 1 - 2 of 2 results for Abreviews and Q&A

      10
      Votes: Highest First

      Customer would like to see proof that this is is an agonistic antibody - how was this tested? And have there been any publications showing this?

      Thank you for your enquiry and patience. Our source for this antibody was able to provide me with the following information. The agonistic properties of the antibody were tested in a proliferation assay with mouse thymocytes (H-thymidine uptake was meas...

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      Can you cite references where this antibody has been used to activate TNFR 2?

      We do not know of any references, although this is a very popular antibody so there are probably some which we are unaware of. We are about to set up an automatic publication update system which should help us identify and then publish references for Abca...

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"