Overview

  • Product nameAnti-TNF Receptor II antibody [HM102]See all TNF Receptor II primary antibodies ...
  • Description
    Rat monoclonal [HM102] to TNF Receptor II
  • SpecificityMouse TNF-R II and the soluble receptor.
  • Tested applicationsIP, IHC-Fr, Flow Cytmore details
  • Species reactivity
    Reacts with: Mouse
  • EpitopeExtra-cellular part of the receptor.

Properties

Applications

Our Abpromise guarantee covers the use of ab7369 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IP
IHC-Fr
Flow Cyt
  • Application notesThe antibody is an agonistic antibody useful for cell culture experiments and for detection of TNF-R II by FACS analysis.
    Furthermore it can be used for immunoprecipitation and histology on frozen sections.
    The reactivity of the antibody with cellbound or soluble TNF-Receptor is not inhibited by high concentrations of mouse TNF-?.
  • Target

    • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
    • Sequence similaritiesContains 4 TNFR-Cys repeats.
    • Post-translational
      modifications
      Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
      A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
    • Cellular localizationSecreted and Cell membrane.
    • Information by UniProt
    • Database links
    • Alternative names
      • CD 120b antibody
      • CD120b antibody
      • CD120b antigen antibody
      • Etanercept antibody
      • p75 antibody
      • p75TNFR antibody
      • p80 TNF alpha receptor antibody
      • p80 TNF-alpha receptor antibody
      • TBP-2 antibody
      • TBP2 antibody
      • TBPII antibody
      • TNF R II antibody
      • TNF R2 antibody
      • TNF R75 antibody
      • TNF-R2 antibody
      • TNF-RII antibody
      • TNFBR antibody
      • TNFR 2 antibody
      • TNFR-II antibody
      • TNFR2 antibody
      • TNFR75 antibody
      • TNFR80 antibody
      • TNFRII antibody
      • TNFRSF 1B antibody
      • TNFRSF1B antibody
      • TNR1B antibody
      • TNR1B_HUMAN antibody
      • Tumor necrosis factor beta receptor antibody
      • Tumor necrosis factor binding protein 2 antibody
      • Tumor necrosis factor receptor 2 antibody
      • Tumor necrosis factor receptor superfamily member 1B precursor antibody
      • Tumor necrosis factor receptor type II antibody
      • Tumor necrosis factor-binding protein 2 antibody
      see all

    References for Anti-TNF Receptor II antibody [HM102] (ab7369)

    This product has been referenced in:
    • Tesz GJ  et al. Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2. J Biol Chem 282:19302-12 (2007). Mouse . Read more (PubMed: 17500068) »

    See 1 Publication for this product

    Product Wall

    Thank you for your enquiry and patience. Our source for this antibody was able to provide me with the following information. The agonistic properties of the antibody were tested in a proliferation assay with mouse thymocytes (H-thymidine uptake was mea...

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    We do not know of any references, although this is a very popular antibody so there are probably some which we are unaware of. We are about to set up an automatic publication update system which should help us identify and then publish references for A...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"