Anti-TNF Receptor II antibody [KT30] (ab53367)

Overview

  • Product nameAnti-TNF Receptor II antibody [KT30]
    See all TNF Receptor II primary antibodies
  • Description
    Mouse monoclonal [KT30] to TNF Receptor II
  • SpecificityDoes not react with human IgG. The antibody does react to soluble TNF Receptor II. However, it is not certain if it reacts to the receptor on the membrane.
  • Tested applicationsFlow Cyt, Indirect ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant soluble human TNFRII-Fc fusion protein

Properties

Applications

Our Abpromise guarantee covers the use of ab53367 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use a concentration of 1 µg/ml.
Indirect ELISA Use a concentration of 5 µg/ml.

Target

  • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Post-translational
    modifications
    Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 120b antibody
    • CD120b antibody
    • CD120b antigen antibody
    • Etanercept antibody
    • p75 antibody
    • p75TNFR antibody
    • p80 TNF alpha receptor antibody
    • p80 TNF-alpha receptor antibody
    • TBP-2 antibody
    • TBP2 antibody
    • TBPII antibody
    • TNF R II antibody
    • TNF R2 antibody
    • TNF R75 antibody
    • TNF-R2 antibody
    • TNF-RII antibody
    • TNFBR antibody
    • TNFR 2 antibody
    • TNFR-II antibody
    • TNFR1B antibody
    • TNFR2 antibody
    • TNFR75 antibody
    • TNFR80 antibody
    • TNFRII antibody
    • TNFRSF 1B antibody
    • TNFRSF1B antibody
    • TNR1B antibody
    • TNR1B_HUMAN antibody
    • Tumor necrosis factor beta receptor antibody
    • Tumor necrosis factor binding protein 2 antibody
    • Tumor necrosis factor receptor 2 antibody
    • Tumor necrosis factor receptor superfamily member 1B antibody
    • Tumor necrosis factor receptor superfamily member 1B precursor antibody
    • Tumor necrosis factor receptor type II antibody
    • Tumor necrosis factor-binding protein 2 antibody
    see all

References for Anti-TNF Receptor II antibody [KT30] (ab53367)

ab53367 has not yet been referenced specifically in any publications.

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