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Anti-TNF Receptor II antibody [MR2-1] (Biotin) (ab16920)

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Overview

  • Product nameAnti-TNF Receptor II antibody [MR2-1] (Biotin)See all TNF Receptor II primary antibodies ...
  • Description
    Mouse monoclonal [MR2-1] to TNF Receptor II (Biotin)
  • ConjugationBiotin
  • Tested applicationsWB, IHC-Fr, Flow Cyt, IP more details
  • Species reactivity
    Reacts with: Human, Cynomolgus Monkey, Rhesus monkey
  • Immunogen

    Human TNF Receptor II

  • Positive controlHuman lymph node (immunohistochemistry) and PHA activated T cells (flow cytometry).

Properties

Applications

Our Abpromise guarantee covers the use of ab16920 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use at an assay dependent dilution. Predicted molecular weight: 55 kDa.
IHC-Fr IHC-Fr: Use at an assay dependent dilution.
Flow Cyt Flow Cyt: Use at an assay dependent dilution.
IP IP: Use at an assay dependent dilution.

Target

  • FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
  • Sequence similaritiesContains 4 TNFR-Cys repeats.
  • Post-translational
    modifications    Phosphorylated; mainly on serine residues and with a very low level on threonine residues.
    A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession P20333 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        CD 120b antibodyCD120b antibodyCD120b antigen antibody
        Etanercept antibodyp75 antibodyp75TNFR antibodyp80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodyTBP-2 antibodyTBP2 antibodyTBPII antibodyTNF R II antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFBR antibodyTNFR 2 antibodyTNFR-II antibodyTNFR2 antibodyTNFR75 antibodyTNFR80 antibodyTNFRII antibodyTNFRSF 1B antibodyTNFRSF1B antibodyTNR1B antibodyTNR1B_HUMAN antibodyTumor necrosis factor beta receptor antibodyTumor necrosis factor binding protein 2 antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor superfamily member 1B precursor antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody
      see all

    References for Anti-TNF Receptor II antibody [MR2-1] (Biotin) (ab16920)

    ab16920 has not yet been referenced specifically in any publications.

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