Anti-TNF Receptor II antibody (ab102741)

Overview

• Product nameAnti-TNF Receptor II antibodySee all TNF Receptor II primary antibodies ...
• Description
  Rabbit polyclonal to TNF Receptor II
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  KLH conjugated synthetic peptide corresponding to a region between amino acids 406-435 from the C terminal region of Human TNF Receptor II (UniProt ID: P20333).

• Positive controlMDA-MB435 cell line lysates

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesThis antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Growth factors
  • TNF

  • Cancer
  • Invasion/microenvironment
  • Angiogenesis
  • Angiogenic growth factors

  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Cardiovascular
  • Atherosclerosis
  • Ischemia / Reperfusion

  • Immunology
  • Innate Immunity
  • Cytokines
  • Necrosis Factors

  • Neuroscience
  • Neurology process
  • Neuroregeneration
  • Neuroregeneration

  • Cell Biology
  • Apoptosis
  • Receptors
  • Death Receptors

Applications

Target

• FunctionReceptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity.
• Sequence similaritiesContains 4 TNFR-Cys repeats.
• Post-translational
  modificationsPhosphorylated; mainly on serine residues and with a very low level on threonine residues.
  A soluble form (tumor necrosis factor binding protein 2) is produced from the membrane form by proteolytic processing.
• Cellular localizationSecreted and Cell membrane.

Target information above from: UniProt accession P20333 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7133 Human
  • Omim: 191191 Human
  • SwissProt: P20333 Human
  • Unigene: 256278 Human

• Alternative names
  CD120b antibodyp75 antibodyp75TNFR antibody

  p80 TNF alpha receptor antibodyp80 TNF-alpha receptor antibodyTBP-2 antibodyTBPII antibodyTNF R2 antibodyTNF R75 antibodyTNF-R2 antibodyTNF-RII antibodyTNFR-II antibodyTNFR80 antibodyTNFRII antibodyTNFRSF1B antibodyTNR1B_HUMAN antibodyTumor necrosis factor receptor 2 antibodyTumor necrosis factor receptor type II antibodyTumor necrosis factor-binding protein 2 antibody

  see all

Anti-TNF Receptor II antibody images

• 

  Western blot - TNF Receptor II antibody - C-terminal (ab102741)
  Anti-TNF Receptor II antibody (ab102741) at 1/100 dilution + MDA-MB435 cell line lysates at 35 µg
  
  Predicted band size : 48 kDa