TNFAIP3 antibody [59A426] (ab13597)

Product Name 

TNFAIP3 antibody [59A426]

Product type 

Primary antibodies

Description 

Mouse monoclonal [59A426] to TNFAIP3

Immunogen 

Recombinant fusion protein of full length A20 (Human).

Reacts with 
(species key)

Hu

Tested applications 
(see key)

WB

Abreviews 

Customer reviews (see key)

Read about Abreviews (Read all Abreviews)

Application notes 
(see key)

Recommended dilutions
WB: Use at a concentration of 3 - 5 µg/ml. Detects a band of approximately 70 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Positive control 
(see definition)

Whole cell lysate from Daudi cells.

Cellular localization 

Cytoplasmic and Nuclear

Research areas 

Cancer >> Growth factors >> TNF
Signal Transduction >> Growth Factors/Hormones >> TNF
Immunology >> Innate Immunity >> Cytokines >> TNF Superfamily

Relevance 

TNFAIP3 interacts with NAF1 and inhibits TNF induced NF kappa B dependent gene expression by interfering with a RIP or TRAF2 mediated transactivation signal. It inhibits programmed cell death, has a role in the function of the lymphoid system, and may contribute to the in vivo effects of TNF.

Database links 

Raised in 

Mouse

Clonality 

Monoclonal

Clone number 

59A426

Isotype 

IgG1

Purity 

Protein G purified

Storage buffer 

Preservative: 0.02% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Form 

Liquid

Concentration 

0.500 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

References for TNFAIP3 antibody [59A426] (ab13597)

  This product has been used in: (two most recent references)

Honma K et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood 114:2467-75 (2009). WB; Human. PubMed: 19608751

Metellus P et al. Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. Cancer 115:4783-94 (2009). IHC-P; Human. PubMed: 19637364

See all 4 publication references for this product.


If you publish research using ab13597 please let us know so that we can cite the reference on this datasheet.

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