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Overview

  • Product nameTNFRSF14 protein (Active)See all TNFRSF14 proteins and peptides ...
  • Protein descriptionRecombinant human TNFRSF14-Fc Chimera is a 376 amino acid fusion protein containing an N-terminal domain corresponding to the extracellular region of TNFRSF14 and a C-terminal domain corresponding to residues 102 to 330 of human IgG1.

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesSource : Insect cells. Purity : Greater than 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg).
  • Biological activityBiological Activity : Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on murine L929 cells. The expected ED50 for this effect is 1.3-1.9 µg/ml of TNFRSF14.
  • FormLyophilised
  • Storage instructionsAliquot and store at -80°C. Avoid repeated freeze / thaw cycles.This product is an active protein and may elicit a biological response in vivo, handle with caution.
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab56291 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
    Functional Studies FuncS: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        HVEMLATARCD258
        CD258 antigenCD270CD40 like protein precursorHerpes virus entry mediator AHerpesvirus entry mediatorHerpesvirus entry mediator AHerpesvirus entry mediator ligandHVEAHVEMHVEM LLIGHTLIGHTRTNFRSF14TNFSF 14TNR14_HUMANTR2Tumor necrosis factor receptor like gene2Tumor necrosis factor receptor superfamily member 14Tumor necrosis factor receptor superfamily member 14 precursorTumor necrosis factor receptor-like 2
      see all
  • FunctionReceptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
  • Tissue specificityWidely expressed, with the highest expression in lung, spleen and thymus.
  • Sequence similaritiesContains 3 TNFR-Cys repeats.
  • Post-translational
    modifications    N-glycosylated.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession Q92956 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for TNFRSF14 protein (Active) (ab56291)

    ab56291 has not yet been referenced specifically in any publications.

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