Anti-TNFRSF1A antibody (ab107860)

Overview

  • Product nameAnti-TNFRSF1A antibodySee all TNFRSF1A primary antibodies ...
  • Description
    Rabbit polyclonal to TNFRSF1A
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 259-288 of Human TNFRSF1A (NP_001056.1).

  • Positive control
    • A549 cell line lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab107860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 50 kDa.

Target

  • FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
  • Involvement in diseaseDefects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
  • Sequence similaritiesContains 1 death domain.
    Contains 4 TNFR-Cys repeats.
  • DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
    Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
  • Post-translational
    modifications
    The soluble form is produced from the membrane form by proteolytic processing.
  • Cellular localizationCell membrane. Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD120a antibody
    • FPF antibody
    • MGC19588 antibody
    • p55 antibody
    • p55 R antibody
    • P55R antibody
    • p60 antibody
    • TBP 1 antibody
    • TBP1 antibody
    • TBPI antibody
    • TNF R antibody
    • TNF R I antibody
    • TNF R55 antibody
    • TNF-R1 antibody
    • TNF-RI antibody
    • TNFAR antibody
    • TNFR 55 antibody
    • TNFR 60 antibody
    • TNFR antibody
    • TNFR-I antibody
    • TNFR1 antibody
    • TNFR55 antibody
    • TNFR60 antibody
    • TNFRI antibody
    • TNFRSF1A antibody
    • TNR1A_HUMAN antibody
    • Tumor necrosis factor alpha receptor antibody
    • Tumor necrosis factor binding protein 1 antibody
    • Tumor necrosis factor receptor 1 antibody
    • Tumor necrosis factor receptor superfamily member 1A antibody
    • Tumor necrosis factor receptor type 1 antibody
    • Tumor necrosis factor receptor type I antibody
    • Tumor necrosis factor-binding protein 1 antibody
    see all

Anti-TNFRSF1A antibody images

  • Anti-TNFRSF1A antibody (ab107860) at 1/100 dilution + A549 cell line lysates at 35 µg

    Predicted band size : 50 kDa

References for Anti-TNFRSF1A antibody (ab107860)

ab107860 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your response.

Of the products which may react in canine only ab13918 has been tested in IHC and WB. However I would still recommend ab22106 as the homology of the regions is greater and it is a polyclonal antibody. You would q...

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Thank you for your response, I apologize as it seem that I lost track of the protein names. We have a few products against RANKwhichshould work with canine samples as the homologies between the protein regions is good. Of those products I would reco...

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Thank you for contacting Abcam. The alignment of the human and canine proteins are very good. As such I can offer you a testing discount for ab107860 (http://www.abcam.com/TNFRSF1A-antibody-ab107860.html) orab111119(http://www.abcam.com/TNFRSF1A-antibo...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"