Anti-TNFRSF1A antibody (ab107860)

Overview

• Product nameAnti-TNFRSF1A antibodySee all TNFRSF1A primary antibodies ...
• Description
  Rabbit polyclonal to TNFRSF1A
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 259-288 of Human TNFRSF1A (NP_001056.1).

• Positive controlA549 cell line lysates

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Growth Factors/Hormones
  • TNF

  • Immunology
  • Immune System Diseases
  • Antiviral Signaling

  • Cell Biology
  • Apoptosis
  • Receptors
  • Associated Proteins

Applications

Target

• FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
• Involvement in diseaseDefects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
• Sequence similaritiesContains 1 death domain.
  Contains 4 TNFR-Cys repeats.
• DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
  Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
• Post-translational
  modificationsThe soluble form is produced from the membrane form by proteolytic processing.
• Cellular localizationCell membrane. Secreted.

Target information above from: UniProt accession P19438 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7132 Human
  • Entrez Gene: 8717 Human
  • Omim: 191190 Human
  • SwissProt: P19438 Human
  • SwissProt: Q15628 Human
  • Unigene: 159 Human
  • Unigene: 279594 Human
  • Unigene: 713833 Human

  • Unigene: 460996 Human

  see all

• Alternative names
  CD120a antibodyFPF antibodyMGC19588 antibody

  p55 antibodyp55 R antibodyP55R antibodyp60 antibodyTBP 1 antibodyTBP1 antibodyTBPI antibodyTNF R antibodyTNF R I antibodyTNF R55 antibodyTNF-R1 antibodyTNF-RI antibodyTNFAR antibodyTNFR 55 antibodyTNFR 60 antibodyTNFR antibodyTNFR-I antibodyTNFR1 antibodyTNFR55 antibodyTNFR60 antibodyTNFRI antibodyTNFRSF1A antibodyTNR1A_HUMAN antibodyTumor necrosis factor alpha receptor antibodyTumor necrosis factor binding protein 1 antibodyTumor necrosis factor receptor 1 antibodyTumor necrosis factor receptor superfamily member 1A antibodyTumor necrosis factor receptor type 1 antibodyTumor necrosis factor receptor type I antibodyTumor necrosis factor-binding protein 1 antibody

  see all

Anti-TNFRSF1A antibody images

• 

  Western blot - TNFRSF1A antibody (ab107860)
  Anti-TNFRSF1A antibody (ab107860) at 1/100 dilution + A549 cell line lysates at 35 µg
  
  Predicted band size : 50 kDa