Anti-TNFRSF1A antibody (ab107860)
- Product nameAnti-TNFRSF1A antibodySee all TNFRSF1A primary antibodies ...
- DescriptionRabbit polyclonal to TNFRSF1A
- Tested applicationsWB more details
- Species reactivityReacts with: Human
Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 259-288 of Human TNFRSF1A (NP_001056.1).
- Positive controlA549 cell line lysates
- Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
- Storage bufferPreservative: 0.09% Sodium Azide
- Concentration information loading...
- PurityImmunogen affinity purified
- Purification notesPurified through a protein A column, followed by peptide affinity purification.
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab107860 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||WB: 1/100 - 1/500. Predicted molecular weight: 50 kDa.|
- FunctionReceptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
- Involvement in diseaseDefects in TNFRSF1A are the cause of familial hibernian fever (FHF) [MIM:142680]; also known as tumor necrosis factor receptor-associated periodic syndrome (TRAPS). FHF is a hereditary periodic fever syndrome characterized by recurrent fever, abdominal pain, localized tender skin lesions and myalgia. Reactive amyloidosis is the main complication and occurs in 25% of cases.
- Sequence similaritiesContains 1 death domain.
Contains 4 TNFR-Cys repeats.
- DomainThe domain that induces A-SMASE is probably identical to the death domain. The N-SMASE activation domain (NSD) is both necessary and sufficient for activation of N-SMASE.
Both the cytoplasmic membrane-proximal region and the C-terminal region containing the death domain are involved in the interaction with TRPC4AP.
modificationsThe soluble form is produced from the membrane form by proteolytic processing.
- Cellular localizationCell membrane. Secreted.
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Anti-TNFRSF1A antibody images
Anti-TNFRSF1A antibody (ab107860) at 1/100 dilution + A549 cell line lysates at 35 µg
Predicted band size : 50 kDa
References for Anti-TNFRSF1A antibody (ab107860)
ab107860 has not yet been referenced specifically in any publications.