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Overview

  • Product nameAnti-TPMT antibodySee all TPMT primary antibodies ...
  • Description
    Mouse monoclonal to TPMT
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-246 of Human TPMT

Properties

Applications

Our Abpromise guarantee covers the use of ab58343 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • FunctionCatalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
    • Involvement in diseaseDefects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency) [MIM:610460]. TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.
    • Sequence similaritiesBelongs to the methyltransferase superfamily. TPMT family.
    • Cellular localizationCytoplasm.

      • Target information above from: UniProt accession P51580 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links
      • Alternative names
          HGNC:12014 antibodyS adenosyl L methionine thiopurine S methyltransferase antibodyThiopurine methyltransferase antibody
          Thiopurine S methyltransferase antibodyThiopurine S-methyltransferase antibodyTPMT antibodyTPMT_HUMAN antibody
        see all

      Anti-TPMT antibody images

      • Western blot - TPMT antibody (ab58343)
        Western blot - TPMT antibody (ab58343)
        Western blot against tagged recombinant protein immunogen using ab58343 TPMT antibody at 1ug/ml. Predicted band size of immunogen is 53 kDa

      References for Anti-TPMT antibody (ab58343)

      ab58343 has not yet been referenced specifically in any publications.

      Publishing research using ab58343 ? Please let us know so that we can cite the reference in this datasheet

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