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Anti-TRAIL antibody [B-S23] (ab27382)

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Overview

Product name

Anti-TRAIL antibody [B-S23]
See all TRAIL products (23) ...

Description

Mouse monoclonal [B-S23] to TRAIL

Specificity

Recognises the TRAIL, APO2 L antigen (32 kDa)

Tested applications

Flow Cytmore details

Cross reactivity

Reacts with

Human

Immunogen

Recombinant full length TRAIL (Human)

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, PBS

Concentration

Concentration information loading...

Purity

Ion Exchange Chromatography

Clonality

Monoclonal

Clone number

B-S23

Myeloma

x63-Ag8.653

Isotype

IgG1

Research areas

Cardiovascular >> Atherosclerosis >> Apoptosis
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> TRAIL
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands

Applications

Show applications key

Our Abpromise guarantee covers the use of ab27382 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Flow Cyt

     

Application notes

Flow Cyt: Use 10µl for 106 cells or 100 µl of whole blood..


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

Tissue specificity

Widespread; most predominant in spleen, lung and prostate.

Sequence similarities

Belongs to the tumor necrosis factor family.

Cellular localization

Membrane.

Target information above from: UniProt accessionP50591 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Apo 2 ligand antibody
  • Apo 2L antibody
  • Apo-2 ligand antibody
  • Apo-2L antibody
  • APO2L antibody
  • CD 253 antibody
  • CD253 antibody
  • CD253 antigen antibody
  • Chemokine tumor necrosis factor ligand superfamily member 10 antibody
  • Protein TRAIL antibody
  • TL 2 antibody
  • TL2 antibody
  • TNF Related Apoptosis Inducing Ligand antibody
  • TNF related apoptosis inducing ligand TRAIL antibody
  • TNF-related apoptosis-inducing ligand antibody
  • TNF10_HUMAN antibody
  • TNFSF 10 antibody
  • TNFSF10 antibody
  • TNFSF10 protein antibody
  • TRAIL antibody
  • TRAIL PEN antibody
  • Tumor necrosis factor (ligand) family member 10 antibody
  • Tumor Necrosis Factor (ligand) Superfamily Member 10 antibody
  • Tumor necrosis factor apoptosis inducing ligand splice variant delta antibody
  • Tumor necrosis factor ligand superfamily member 10 antibody
see all

Database links

References for Anti-TRAIL antibody [B-S23] (ab27382)

This product has been referenced in:

  • Herbeuval JP  et al. TNF-related apoptosis-inducing ligand (TRAIL) in HIV-1-infected patients and its in vitro production by antigen-presenting cells. Blood 105:2458-64 (2005).Read more (PubMed: 15585654) »

See 1 publication for this product

Publishing research using ab27382? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"