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- Proteins and Peptides
- Secondary antibodies
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Product name
Anti-TRAIL antibody
See all TRAIL products (23) ...
Description
Rabbit polyclonal to TRAIL
Specificity
Human.
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide, corresponding to amino acids 261-277 of Human TRAIL.
Epitope
CTNEHLIDMDHEASFFGA
Positive control
HeLa whole cell lysate.
General notes
Ligand for DR4 and DR5.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.02% sodium azide
Concentration
Concentration information loading...
Purity
IgG fraction
Clonality
Polyclonal
Isotype
IgG
Research areas
Cardiovascular >> Atherosclerosis >> Apoptosis
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> TRAIL
Cell Biology >> Apoptosis >> Extracellular Signals >> Death Ligands
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2056 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application notes
IHC-P: Use at a concentration of 20 µg/ml.
WB: (1:500) gives a 32 kD band. This represents the membrane-bound form of TRAIL.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Tissue specificity
Widespread; most predominant in spleen, lung and prostate.
Sequence similarities
Belongs to the tumor necrosis factor family.
Cellular localization
Membrane.
Target information above from: UniProt accessionP50591
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Apo 2 ligand antibody
- Apo 2L antibody
- Apo-2 ligand antibody
see all
Database links
- Entrez Gene: 8743 Human
- Omim: 603598 Human
- SwissProt: P50591 Human
- Unigene: 478275 Human
Anti-TRAIL antibody images:
Western blot - TRAIL antibody (ab2056)
Western blot analysis of HeLa cell lysate containing 10, 2.5, or 1 ng of recombinant protein containing extracellular domain of TRAIL with anti-TRAIL at 1 µg/ml.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRAIL antibody (ab2056)
Immunohistochemistry of TRAIL in human brain tissue with TRAIL antibody at 20 µg/ml.
References for Anti-TRAIL antibody (ab2056)
ab2056 has not yet been referenced specifically in any publications.
Publishing research using ab2056? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"