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Product name
Anti-TRIM5 gamma antibody
See all TRIM5 gamma products (2) ...
Description
Rabbit polyclonal to TRIM5 gamma
Tested applications
IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide (Human) (C terminal).
Positive control
Human bladder and colon cell lysates.
Properties
Form
Liquid
Storage instructions
Store at +4°C.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ub-like Proteins
Applications
Show applications key
Our Abpromise guarantee covers the use of ab17203 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-P: Use a concentration of 2 µg/ml.
WB: Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 35 kDa.
Target
Function
Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.
Pathway
Protein modification; protein ubiquitination.
Sequence similarities
Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.
Domain
The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.
Post-translational
modifications
Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).
Cellular localization
Cytoplasm > P-body. Cytoplasmic bodies.
Target information above from: UniProt accessionQ9C035
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- RING finger protein 88 antibody
- RNF88 antibody
- TRIM5 antibody
see all
Database links
- Entrez Gene: 85363 Human
- Omim: 608487 Human
- SwissProt: Q9C035 Human
- Unigene: 370515 Human
Anti-TRIM5 gamma antibody images:
Western blot - TRIM5 gamma antibody (ab17203)
All lanes : Anti-TRIM5 gamma antibody (ab17203) at 2 µg/ml
Lane 1 : Human bladder cell lysate
Lane 2 : Human colon cell lysate
Observed band size : 35 kDa (why is the actual band size different from the predicted?)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - TRIM5 gamma antibody (ab17203)
ab17203 at 2µg/ml staining TRIM5 gamma in human bladder tissue by IHC
References for Anti-TRIM5 gamma antibody (ab17203)
ab17203 has not yet been referenced specifically in any publications.
Publishing research using ab17203? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"