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TRIM5 gamma peptide (ab41839)

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Overview

Product name

TRIM5 gamma peptide

Protein description

15 amino acids near the carboxy terminus of human TRIM5 gamma. This peptide was used as an immunogen for ab17203 - TRIM5 gamma antibody.

Properties

Purification notes

60-70% purity.

Biological activity

Blocking the activity of the TRIM5 gamma antibody (ab17203).

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: 0.1% BSA, PBS, pH 7.2

Concentration

Concentration information loading...

Research areas

Cell Biology >> Proteolysis / Ubiquitin >> Proteasome / Ubiquitin >> Ub-like Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab41839 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Blocking

     

Application notes

BL: Use at an assay dependent dilution.

Incubating the peptide with equal volume of antibody for 30 min at 37°C usually completely blocks the antibody activity in Western blotting.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Protein info

Function

Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity.

Pathway

Protein modification; protein ubiquitination.

Sequence similarities

Belongs to the TRIM/RBCC family.
Contains 1 B box-type zinc finger.
Contains 1 B30.2/SPRY domain.
Contains 1 RING-type zinc finger.

Domain

The RING-type zinc finger domain mediates binding to an E2 ubiquitin-conjugating enzyme.

Post-translational
modifications

Ubiquitinates itself in a RING finger- and UBE2D2-dependent manner (in vitro).

Cellular localization

Cytoplasm > P-body. Cytoplasmic bodies.

Target information above from: UniProt accessionQ9C035 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for TRIM5 gamma peptide (ab41839)

ab41839 has not yet been referenced specifically in any publications.

Publishing research using ab41839? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"