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Products:Neuroscience >> Neurotransmission >> Receptors / Channels >> More Ion Channels
Overview
Product name
Anti-TRPV4 antibody
See all TRPV4 products (12) ...
Description
Sheep polyclonal to TRPV4
Tested applications
WB, IHC-Fr, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide as a part of mouse, human and rat TRPV4 conjugated to an immunogenic carrier protein.
Properties
Form
Lyophilised:
Please reconstitute this product in 100ul sterile water.
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C (add glycerol to a final volume of 50% for extra stability). Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: PBS (prior to lyophilization), Whole serum
Concentration
Concentration information loading...
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Sensory System >> Somatosensory system >> Nociception
Neuroscience >> Neurotransmission >> Receptors / Channels >> More Ion Channels
Applications
Show applications key
Our Abpromise guarantee covers the use of ab63079 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
IHC-Fr
IHC-P
Application notes
IHC-Fr: 1/300 - 1/4000.
IHC-P: 1/300 - 1/4000. Antigen retrieval is recommended.
WB: 1/300 - 1/4000. Predicted molecular weight: 98 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The detection of noxious stimuli (chemical, mechanical, or thermal) occurs predominantly at the peripheral terminals of primary afferent neurons. This information is ultimately transmitted to the central nervous system to evoke appropriate protective reflexes. TRPV4 is a non selective calcium permeant, swell activated, cation channel probably involved in osmotic and mechano sensitivity. Activation by exposure to hypotonicity within the physiological range, low pH, citrate and phorbol esters exhibits an outward rectification. Once activated the channel seems to be regulated in a calmodulin dependent manner, with a negative feedback mechanism.
Cellular localization
Multi-pass membrane protein
Alternative names
- osm 9 like TRP channel 4 antibody
- OTRPC 4 antibody
- OTRPC4 antibody
see all
Database links
- Entrez Gene: 59341 Human
- Entrez Gene: 63873 Mouse
- Entrez Gene: 66026 Rat
- Omim: 605427 Human
- SwissProt: Q9HBA0 Human
- SwissProt: Q9EPK8 Mouse
- SwissProt: Q9ERZ8 Rat
- Unigene: 506713 Human
see all
References for Anti-TRPV4 antibody (ab63079)
ab63079 has not yet been referenced specifically in any publications.
Publishing research using ab63079? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"