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Overview

  • Product nameAnti-TSH antibody [TSH 220]See all TSH primary antibodies ...
  • Description
    Mouse monoclonal [TSH 220] to TSH
  • Specificityab76759 labels thyrotrophic cells of the pituitary and may be useful for research in the classification of pituitary adenocarcinomas and differential identification of primary and metastatic tumors of the pituitary.
  • Tested applicationsIHC-P, IHC-Fr, ICC more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human TSH, beta subunit.

  • Epitopenot known
  • Positive controlHuman Anterior pituitary tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab76759 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P
IHC-Fr
ICC
  • Application notesICC: 1/50 - 1/100.
    Note: this antibody can be used also in cell smears.

    IHC-P: 1/50 - 1/100 using streptavidin-Biotin system or polymer system.
    Note: The intensity of staining can be enhanced by antigen retriever (boiling tissue in 10 mM citrate, pH 6.0 for 15-20 mins, followed by cooling at RT for 20 mins).

    IHC-Fr: 1/50 - 1/100 using streptavidin-Biotin system or polymer system.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceThyroid stimulating hormone, also known as thyrotropin, is secreted from cells in the anterior pituitary called thyrotrophs, finds its receptors on epithelial cells in the thyroid gland, and stimulates that gland to synthesize and release thyroid hormones. TSH is a glycoprotein hormone composed of two subunits which are non covalently bound to one another. The alpha subunit of TSH is also present in two other pituitary glycoprotein hormones, follicle stimulating hormone and luteinizing hormone, and, in primates, in the placental hormone chorionic gonadotropin. Each of these hormones also has a unique beta subunit, which provides receptor specificity. In other words, TSH is composed of alpha subunit bound to the TSH beta subunit, and TSH associates only with its own receptor. Free alpha and beta subunits have essentially no biological activity.
    • Cellular localizationSecreted
    • Database links
      • Alternative names
          Anterior pituitary glycoprotein hormones common subunit alpha antibodyCG ALPHA antibodyCGA antibody
          CGA protein antibodyChoriogonadotropin alpha chain antibodyChorionic gonadotrophin alpha subunit antibodyChorionic gonadotropin alpha polypeptide antibodyFollicle stimulating hormone alpha chain antibodyFollitropin alpha chain antibodyFSH alpha antibodyFSHA antibodyGlycoprotein hormones alpha chain antibodyGlycoprotein hormones alpha polypeptide antibodyGPHa antibodyGPHA1 antibodyHCG antibodyLHA antibodyLSH alpha antibodyLuteinizing hormone alpha chain antibodyLutropin alpha chain antibodyThyroid stimulating hormone alpha chain antibodyThyroid stimulating hormone beta antibodyThyroid stimulating hormone beta subunit antibodyThyroid stimulating hormone subunit beta antibodyThyroid Stimulation Hormone antibodyThyrotropin alfa antibodyThyrotropin alpha chain antibodyThyrotropin beta subunit antibodyThyrotropin subunit beta antibodyTSH A antibodyTSH alpha antibodyTSH B antibodyTSH beta antibodyTSHA antibodyTSHB antibody
        see all

      References for Anti-TSH antibody [TSH 220] (ab76759)

      ab76759 has not yet been referenced specifically in any publications.

      Publishing research using ab76759 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"