Overview

  • Product nameAnti-TUBA6 antibody
    See all TUBA6 primary antibodies
  • Description
    Mouse monoclonal to TUBA6
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-450 of Human TUBA6

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • Clonality Monoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab57905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionTubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain.
    • Sequence similaritiesBelongs to the tubulin family.
    • Post-translational
      modifications
      Undergoes a tyrosination/detyrosination cycle, the cyclic removal and re-addition of a C-terminal tyrosine residue by the enzymes tubulin tyrosine carboxypeptidase (TTCP) and tubulin tyrosine ligase (TTL), respectively.
      Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules.
      Acetylation of alpha-tubulins at Lys-40 stabilizes microtubules and affects affinity and processivity of microtubule motors. This modification has a role in multiple cellular functions, ranging from cell motility, cell cycle progression or cell differentiation to intracellular trafficking and signaling.
    • Cellular localizationCytoplasm > cytoskeleton.
    • Information by UniProt
    • Database links
    • Alternative names
      • Alpha tubulin 6 antibody
      • Alpha tubulin isotype M alpha 6 antibody
      • Alpha-tubulin 6 antibody
      • bcm948 antibody
      • M[a]6 antibody
      • TBA1C_HUMAN antibody
      • Tuba1c antibody
      • Tubulin alpha 1C chain antibody
      • tubulin alpha 6 antibody
      • Tubulin alpha 6 chain antibody
      • Tubulin alpha-1C chain antibody
      • Tubulin alpha-6 chain antibody
      • tubulin, alpha 1c antibody
      see all

    Anti-TUBA6 antibody images



    • Predicted band size : 50 kDa
      TUBA6 antibody (ab57905) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-TUBA6 antibody (ab57905)

    ab57905 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab57905.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"