Overview

  • Product name
    Anti-TUSC2 antibody
  • Description
    Rabbit polyclonal to TUSC2
  • Tested applications
    Suitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide derived from an internal region of human TUSC2.

  • Positive control
    • extracts from HeLa cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab70182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Detects a band of approximately >19 kDa (predicted molecular weight: 12 kDa).
ELISA 1/5000.

Target

  • Function
    May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.
  • Tissue specificity
    Strong expression in heart, lung, skeletal muscle, kidney, and pancreas, followed by brain and liver, lowest levels in placenta.
  • Sequence similarities
    Belongs to the TUSC2 family.
  • Post-translational
    modifications
    Myristoylation is required for tumor suppressor activity.
  • Information by UniProt
  • Database links
  • Alternative names
    • C3orf11 antibody
    • Fus-1 protein antibody
    • FUS1 antibody
    • Fusion 1 protein antibody
    • LGCC antibody
    • PAP antibody
    • PDAP2 antibody
    • PDGFA associated protein 2 antibody
    • PDGFA-associated protein 2 antibody
    • Tumor suppressor candidate 2 antibody
    • TUSC 2 antibody
    • Tusc2 antibody
    • TUSC2_HUMAN antibody
    see all

Images

  • All lanes : Anti-TUSC2 antibody (ab70182) at 1/500 dilution

    Lane 1 : HeLa cell extract
    Lane 2 : HeLa cell extract with immunising peptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 12 kDa
    Observed band size : <19 kDa (why is the actual band size different from the predicted?)

References

This product has been referenced in:
  • Yamamoto K  et al. Uncovering Direct Targets of MiR-19a Involved in Lung Cancer Progression. PLoS One 10:e0137887 (2015). WB ; Human . Read more (PubMed: 26367773) »
  • Rutnam ZJ  et al. The pseudogene TUSC2P promotes TUSC2 function by binding multiple microRNAs. Nat Commun 5:2914 (2014). WB ; Mouse . Read more (PubMed: 24394498) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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