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Product name
Anti-TYK2 antibody
See all TYK2 products (9) ...
Description
Rabbit polyclonal to TYK2
Specificity
This antibody detects endogenous levels of TYK2 protein around Tyrosine 1054.
Tested applications
ELISA, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic non-phosphopeptide derived from human TYK2 around the phosphorylation site of Tyrosine 1054.
Positive control
Human breast carcinoma tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: 50% Glycerol, PBS, 150mM Sodium chloride, pH 7.4
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
-
Immunohistochemistry (Paraffin-embedded sections) - TYK2 antibody (ab39550)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab39550 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
ELISA: 1/10000.ELISA: 1/10000.
IHC-P: 1/50 - 1/100.
Target
Function
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
Tissue specificity
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines.
Involvement in disease
Defects in TYK2 are the cause of protein-tyrosine kinase 2 deficiency (TYK2 deficiency) [MIM:611521]; also known as autosomal recessive hyper-IgE syndrome (HIES) with atypical mycobacteriosis. TYK2 deficiency consists of a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Sequence similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
Contains 1 FERM domain.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Domain
The FERM domain mediates interaction with JAKMIP1.
Target information above from: UniProt accessionP29597
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- JTK 1 antibody
- JTK 1 antibody
- JTK1 antibody
see all
Database links
- Entrez Gene: 7297 Human
- Entrez Gene: 54721 Mouse
- Entrez Gene: 298706 Rat
- Omim: 176941 Human
- SwissProt: P29597 Human
- SwissProt: Q3TXE3 Mouse
- SwissProt: Q3U447 Mouse
- SwissProt: Q3TIS9 Mouse
see all
Anti-TYK2 antibody images:
Immunohistochemistry (Paraffin-embedded sections) - TYK2 antibody (ab39550)
Immunohistochemical analysis of paraffin-embedded human breast carcinoma, using ab39550 (10-20µg/ml). Left: Untreated; Right: Treated with synthesized peptide.
References for Anti-TYK2 antibody (ab39550)
ab39550 has not yet been referenced specifically in any publications.
Publishing research using ab39550? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"