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Products:Cell Biology >> Cell Cycle >> Cell differentiation
Overview
Product name
Anti-Tal1 antibody
See all Tal1 products (3) ...
Description
Rabbit polyclonal to Tal1
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide (Human) corresponding to amino acid residues surrounding T90, conjugated to KLH.
Positive control
Jurkat cell lysate
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Purification notes
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality
Polyclonal
Isotype
IgG
Research areas
Developmental Biology >> Organogenesis >> Hematopoietic system development
Stem Cells >> Hematopoietic Progenitors >> Hemangioblast
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Hematopoietic Progenitors >> Intracellular Molecules
Epigenetics and Nuclear Signaling >> Cell cycle >> Cell Differentiation
Cell Biology >> Cell Cycle >> Cell differentiation
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Western blot - Tal1 antibody (ab75738)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab75738 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/50 - 1/100.Predicted molecular weight: 34 kDa.
ELISA
ELISA: 1/1000ELISA: 1/1000
Target
Function
Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.
Tissue specificity
Leukemic stem cell.
Involvement in disease
Note=A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.
Sequence similarities
Contains 1 basic helix-loop-helix (bHLH) domain.
Domain
The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.
Post-translational
modifications
Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.
Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.
Cellular localization
Nucleus.
Target information above from: UniProt accessionP17542
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- bHLHa17 antibody
- Class A basic helix-loop-helix protein 17 antibody
- OTTHUMP00000009563 antibody
see all
Database links
- Entrez Gene: 6886 Human
- Omim: 187040 Human
- SwissProt: P17542 Human
- Unigene: 705618 Human
- Unigene: 73828 Human
Anti-Tal1 antibody images:
Western blot - Tal1 antibody (ab75738)
Anti-Tal1 antibody (ab75738) at 1/50 dilution + Jurkat cell lysate at 35 µg
Predicted band size : 34 kDa
Observed band size : 38 kDa (why is the actual band size different from the predicted?)
References for Anti-Tal1 antibody (ab75738)
ab75738 has not yet been referenced specifically in any publications.
Publishing research using ab75738? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"