Overview

  • Product nameAnti-Tau 13 antibody [TAU-13]See all Tau 13 primary antibodies ...
  • Description
    Mouse monoclonal [TAU-13] to Tau 13
  • Specificityab24634 reacts with tau protein - isoform Tau13.
  • Tested applicationsICC/IF, WB, IP, ELISA, IHC-P more details
  • Species reactivity
    Reacts with: Human

    Does not react with

    Mouse, Rat, Cow
  • Immunogen

    Polymeric form of the longest human tau isoform.

  • EpitopePreliminary assignment of its epitope indicates that it maps to amino acid residues 2-18 on the longest isoform of human tau.
  • General notes


    ab24634 binds to human tau and is able to stain brain tissue early in Alzheimer’s disease.

Properties

Applications

Our Abpromise guarantee covers the use of ab24634 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
ICC/IF Use at an assay dependent concentration. PubMed: 22558197
WB 1/5000. Predicted molecular weight: 45-60 kDa.
IP 1/5000.
ELISA 1/5000.
IHC-P Use at an assay dependent concentration. PubMed: 22174735

Target

  • RelevanceTau is a neuronal microtubule-associated protein found predominantly on axons. The function of tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF)and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK 3 beta, PKA, Cdk 5, and casein kinase II can phosphorylate tau.
  • Cellular localizationCytoplasmic and Plasma membrane
  • Database links
  • Alternative names
    • DDPAC antibody
    • FLJ31424 antibody
    • FTDP 17 antibody
    • FTDP17 antibody
    • G protein beta1/gamma2 subunit interacting factor 1 antibody
    • MAPT antibody
    • MGC138549 antibody
    • Microtubule associated protein tau antibody
    • MSTD antibody
    • MTBT 1 antibody
    • MTBT 2 antibody
    • MTBT1 antibody
    • MTBT2 antibody
    • Neurofibrillary tangle protein antibody
    • Paired helical filament tau antibody
    • PHF tau antibody
    • PPND antibody
    • TAU antibody
    see all

References for Anti-Tau 13 antibody [TAU-13] (ab24634)

This product has been referenced in:
  • Liu C & Götz J Profiling murine tau with 0N, 1N and 2N isoform-specific antibodies in brain and peripheral organs reveals distinct subcellular localization, with the 1N isoform being enriched in the nucleus. PLoS One 8:e84849 (2013). WB . Read more (PubMed: 24386422) »
  • Ke Y  et al. Tau-Mediated Nuclear Depletion and Cytoplasmic Accumulation of SFPQ in Alzheimer's and Pick's Disease. PLoS One 7:e35678 (2012). ICC/IF ; Human . Read more (PubMed: 22558197) »

See all 3 Publications for this product

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"