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Overview

  • Product nameTcl1 peptideSee all Tcl1 proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 1 - 100 of Human Tcl1.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab32813 - Tcl1 antibody.
  • Protein length114 amino acids

    • Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab32813.

    • Protein info

    • Alternative names
        anti TCL1AOncogene TCL-1Oncogene TCL1
        P14 TCL1P14 TCL1 proteinProtein p14 TCL1T cell leukemia 1T cell lymphoma 1T cell lymphoma 1AT-cell leukemia/lymphoma protein 1ATCL 1 proteinTCL1TCL1 oncogeneTCL1 PENTCL1ATCL1A antibodyTCL1A_HUMAN
      see all
  • FunctionEnhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival.
  • Tissue specificityRestricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation.
  • Involvement in diseaseNote=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
  • Sequence similaritiesBelongs to the TCL1 family.
  • Cellular localizationCytoplasm. Nucleus. Microsome. Endoplasmic reticulum. Microsomal fraction.

    • Target information above from: UniProt accession P56279 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Tcl1 peptide (ab38395)

    This product has been referenced in:
    • LaPan P  et al. Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum. BMC Pulm Med 10:40 (2010). ELISA . Read more (PubMed: 20678199) »

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