Overview

  • Product nameTetrodotoxin
  • Description
    Na+ channel blocker
  • Alternative names
    • TTX
  • Biological descriptionPotent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
  • Purity> 98%
  • General notes

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Properties

    Tetrodotoxin images

    • TTX blocked the ictal discharge in both field A and B neurons, but not the direct response of field A neurons to a double NMDA pulse (black arrowheads).
    • Multiple connections between CA3 and CA1 pyramidal cells and GABAergic cells and CA1 pyramidal cells in young adult rats. (A1) A typical recording at -80 mV from a pyramidal cell, upper trace shows AMPA sEPSCs under control conditions and lower trace shows mEPSCs after wash-in of TTX. (A2) TTX reduces the AMPA EPSC amplitude by 5.9 ± 0.8 pA (P = 0.004, n = 8, two-tailed paired t-test). (A3) TTX reduces AMPA EPSC frequency by 1.5 ± 0.4 Hz (P < 0.001, n = 8, one-tailed paired t-test). (A4) The average multiplicity was 1.7 ± 0.1 (P < 0.001, n = 8, one-tailed one-sample t-test with test value = 1). (B1) A typical recording at 0 mV from a pyramidal cell, upper trace shows GABA sIPSCs under control conditions and lower trace shows mIPSCs after wash-in of TTX. (B2) TTX reduces the GABA IPSC amplitude by 8.4 ± 2.7 pA (P = 0.03, n = 6, two-tailed paired t-test). (B3) TTX reduces GABA IPSC frequency by 3.2 ± 0.8 Hz (P = 0.005, n = 6, one-tailed paired t-test). (B4) The average multiplicity was 2.4 ± 0.4 (P = 0.007, n = 6, one-tailed one-sample t-test with test value = 1). Black filled circles show mean ± SEM and green filled circles show data from individual experiments. Asterisks denote the level of significance as follows: *: P < 0.05, **: P < 0.01, ***: P < 0.001.

    References for Tetrodotoxin (ab120054)

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    Product Wall

    The specific molarity of the citrate buffer used to solubilize TTX (ab120054) is not as significant as the pH of 4.8. You can essentially use the molarity of citrate buffer that will be applicable with your specific study. As a general guideline for a ...

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    The water-soluble TTX citrate ab120055 is not a citrate salt, it is simply TTX that has been dissolved in a citrate solution, and then lyophilized. So, it has the same molecular weight and formula as ab120054, which is soluble in pH 4.8 citrate buffer ...

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    The following information is published on the datasheet;

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Where...

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    Despite extensive checking, including the RTECS database, we can find no toxicity data for inhalation (or skin contact) for TTX. In theory, we are not obliged to include any classification for these routes of entry if no data can be found. Obviously, w...

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    I contacted the laboratory regarding the difference between ab120054 and ab120055, and they responded that the only difference between these two compounds is that TTX citrate (ab120055) is the water soluble version, which accounts for the differen...

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    Here are certificates of analysis for the product and lot numbers you have been assigned for your orders (PO numer xxxxx, orders xxxxx and xxxxxx).


    If there are any problems please do let me know.

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    SL 327 (ab120082) and Kainic acid (ab120100) are both produced at >98% purity as determined by HPLC. I am checking which lots of these products have been assigned to you and then I will send the certificate ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"