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Product name
Thapsigargin
Description
Ca2+-ATPase inhibitor
Biological description
A potent, cell-permeable Ca2+-ATPase inhibitor. Releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Both tumorogenic and apoptotic actions reported.
Purity
> 98%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Molecular Weight
650.75
Chemical structure
Molecular formula
C34H50O12
CAS Number
67526-95-8
Solubility
Soluble in DMSO to 100 mM
PubChem identifier
0
Storage instructions
Store at -20°C (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Obesity >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Hypertension >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Heart disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Diabetes >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Cancer >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Research Area >> Stroke >> Calcium
Biochemicals >> Research Area >> Respiratory disease >> Calcium
Biochemicals >> Research Area >> Pain & inflammation >> Calcium
Biochemicals >> Research Area >> Obesity >> Calcium
Biochemicals >> Research Area >> Hypertension >> Calcium
Biochemicals >> Research Area >> Heart disease >> Calcium
Biochemicals >> Research Area >> Diabetes >> Calcium
Biochemicals >> Pharmacology >> Receptors & Transporters >> Transporters >> Ion pumps / transporter >> Ca2+-ATPase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Ca2+ signaling >> Ca2+-ATPase
Biochemicals >> Pharmacology >> Enzymes >> ATPase & GTPase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Thapsigargin (ab120286)
This product has been referenced in:
- Treiman M et al. A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. Trends Pharmacol Sci 19:131-5 (1998).Read more (PubMed: 9612087) »
See 1 publication for this product
Publishing research using ab120286? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"