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AbcamBiochemicals (Asc-751)

Thioflavin T (ab120751)

Q&A (1)

Overview

  • Product nameThioflavin T
  • Description
    Fluorescent cell permeable amyloid binding benzothiazol salt
  • Biological descriptionFluorescent cell permeable amyloid binding benzothiazol salt. Dye used to visualise stacked β sheets in vitro and in vivo. Binding induces a shift in excitation maximum (385 nm to 450 nm) and emissions maximum (445 nm to 482 nm). Highly soluble in water. Limited ability to cross the blood brain barrier.
  • Purity> 97%

    • Properties

  • Chemical name4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
  • Molecular Weight318.86
  • Chemical structureChemical Structure
  • Molecular formulaC17H19ClN2S
  • CAS Number2390-54-7
  • Storage instructionsStore at room temperature.
  • Solubility overviewSoluble in water to 100 mM (with warming) and in DMSO to 100 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • Source

    Synthetic

  • Research Areas

    • References for Thioflavin T (ab120751)

    This product has been referenced in:
    • Biancalana M & Koide S Molecular mechanism of Thioflavin-T binding to amyloid fibrils. Biochim Biophys Acta 1804:1405-12 (2010). Read more (PubMed: 20399286) »
    • Darghal N  et al. Mechanism of thioflavin T accumulation inside cells overexpressing P-glycoprotein or multidrug resistance-associated protein: role of lipophilicity and positive charge. Biochem Biophys Res Commun 343:623-9 (2006). Read more (PubMed: 16554036) »

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    Can Thioflavin T be used on frozen tissue?

    Thioflavin T has widely been used in frozen tissue so this product should work in frozen tissue.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"