Thioperamide maleate, H3 antagonist (ab120021)
Key features and details
- Potent, selective H3 antagonist
- CAS Number: 148440-81-7
Soluble in water to 50 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Thioperamide maleate, H3 antagonist -
Description
Potent, selective H3 antagonist -
Biological description
Potent, selective H3 antagonist that crosses the blood-brain barrier.
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CAS Number
148440-81-7 -
Chemical structure
Properties
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Chemical name
N-Cyclohexyl-4-(imidazol-4-yl)-1-piperidinecarbothioamide maleate
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Molecular weight
408.51 -
Molecular formula
C15H24N4S.C4H4O4 -
PubChem identifier
11211984 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water to 50 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
S=C(NC1CCCCC1)N2CCC(CC2)c3cncn3.O=C(O)/C=CC(=O)O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (5)
ab120021 has been referenced in 5 publications.
- Wang N et al. Histamine H3 Receptor Antagonist Enhances Neurogenesis and Improves Chronic Cerebral Hypoperfusion-Induced Cognitive Impairments. Front Pharmacol 10:1583 (2019). PubMed: 32038255
- Olszewska B et al. 4-Hydroxypiperidines and Their Flexible 3-(Amino)propyloxy Analogues as Non-Imidazole Histamine H3 Receptor Antagonist: Further Structure?Activity Relationship Exploration and In Vitro and In Vivo Pharmacological Evaluation. Int J Mol Sci 19:N/A (2018). PubMed: 29671795
- Zhou X et al. Electrophysiological and Pharmacological Analyses of Nav1.9 Voltage-Gated Sodium Channel by Establishing a Heterologous Expression System. Front Pharmacol 8:852 (2017). PubMed: 29213238
- Frandsen IO et al. Identification of Histamine H3 Receptor Ligands Using a New Crystal Structure Fragment-based Method. Sci Rep 7:4829 (2017). PubMed: 28684785
- Masini D et al. The histamine H3 receptor antagonist thioperamide rescues circadian rhythm and memory function in experimental parkinsonism. Transl Psychiatry 7:e1088 (2017). PubMed: 28398338