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Products:Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
Overview
Product name
Anti-Thrombopoietin antibody
See all Thrombopoietin products (9) ...
Description
Rabbit polyclonal to Thrombopoietin
Specificity
Cross reactivity: Thrombopoietin Human (299-332) 100%; Thrombopoietin Human recombinant ~90% Does not cross react with Erythropoietin Human recombinant.
Tested applications
ICC/IF, IHC-P, WBmore details
Cross reactivity
Reacts with
Human
Predicted to work with
Chimpanzee
Immunogen
Synthetic peptide: PPTGQYTLFP LPPTLPTPVV QLHPLLPDPS APTP conjugated to KLH, corresponding to amino acids 299-332 of Human Thrombopoietin Peptide available as ab93626.
PPTGQYTLFP LPPTLPTPVV QLHPLLPDPS APTP
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks) (add antibacterial agent). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: Whole serum
Purity
Whole antiserum
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cell cycle >> Cell differentiation
Stem Cells >> Mesenchymal Stem Cells >> Osteogenesis
Cell Biology >> Cell Cycle >> Cell differentiation
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
Applications
Show applications key
Our Abpromise guarantee covers the use of ab40664 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC/IF
ICC/IF: 1/500ICC/IF: 1/500
IHC-P: Use at an assay dependent dilution. (PubMed: 21149592)
WB: 1/800Detects a band of approximately 59 kDa (predicted molecular weight: 38 kDa).Can be blocked with Thrombopoietin peptide (299-332) (ab93626). (With this antibody, we have found that blocking with 5% goat or donkey serum significantly reduces background as compared to BSA or milk. )
Target
Function
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Involvement in disease
Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
Sequence similarities
Belongs to the EPO/TPO family.
Domain
Two-domain structure with an erythropoietin-like N-terminal and a Ser/Pro/Thr-rich C-terminal.
Cellular localization
Secreted.
Target information above from: UniProt accessionP40225
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- c mpl ligand antibody
- c mpl ligand antibody
- C-mpl ligand antibody
see all
Database links
- Entrez Gene: 7066 Human
- Omim: 600044 Human
- SwissProt: P40225 Human
- Unigene: 1166 Human
References for Anti-Thrombopoietin antibody (ab40664)
This product has been referenced in:
- Hoffmann Oet al. Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis. Infect Immun 79:928-36 (2011). IHC-P; Human.Read more (PubMed: 21149592) »
See 1 publication for this product
Publishing research using ab40664? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"