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Anti-Thrombospondin antibody [A65M] (ab23420)

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Overview

Product name

Anti-Thrombospondin antibody [A65M]
See all Thrombospondin products (11) ...

Description

Mouse monoclonal [A65M] to Thrombospondin

Specificity

ab23420 is highly specific for the low-calcium conformation of thrombospondin. There is no cross-reactivity with other connective tissue proteins (vitronectin, fibronectin, elastin, collagen, laminin).

Tested applications

IP, IHC-Fr, ELISAmore details

Cross reactivity

Reacts with

Cow, Human

Immunogen

Corneal endothelial cells on beads (Cow).

Epitope

Epitope is only present in thrombospondin prepared with low levels of calcium

Properties

Form

Liquid

Storage instructions

Store at +4°C in the dark.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: 0.5M Sodium chloride, 0.01M PBS, pH 7.4

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Monoclonal

Clone number

A65M

Myeloma

Sp2/0

Isotype

IgG1

Research areas

Cancer >> Cancer Metabolism >> Response to hypoxia
Cancer >> Invasion/microenvironment >> Angiogenesis >> Angiogenic inhibitory factors
Stem Cells >> Signaling Pathways >> TGF beta >> Secreted
Neuroscience >> Cell Adhesion Proteins >> Cytoskeletal Proteins >> Regulation
Cardiovascular >> Blood >> Coagulation >> Regulatory
Cardiovascular >> Blood >> Platelets
Cardiovascular >> Blood >> Fibrinolysis / Thrombolysis
Neuroscience >> Cell Type Marker >> Glia marker >> Astrocyte marker

Applications

Show applications key

Our Abpromise guarantee covers the use of ab23420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    IP

     IP: Use at an assay depe...Read more →

    IP: Use at an assay dependent dilution.

  • ShowHide

    IHC-Fr

     IHC-Fr: 1/40(PLP-fixed s...Read more →

    IHC-Fr: 1/40(PLP-fixed sections of bovine and human tissues.)

  • ELISA

     ELISA: 1/200

    ELISA: 1/200

Target

Function

Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions.

Sequence similarities

Belongs to the thrombospondin family.
Contains 3 EGF-like domains.
Contains 1 TSP C-terminal (TSPC) domain.
Contains 1 TSP N-terminal (TSPN) domain.
Contains 3 TSP type-1 domains.
Contains 8 TSP type-3 repeats.
Contains 1 VWFC domain.

Target information above from: UniProt accessionP07996 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • THBS 1 antibody
  • THBS antibody
  • THBS1 antibody
  • Thrombospondin 1 antibody
  • Thrombospondin-1 antibody
  • Tsp 1 antibody
  • TSP antibody
  • Tsp1 antibody
  • TSP1_HUMAN antibody
see all

Database links

References for Anti-Thrombospondin antibody [A65M] (ab23420)

This product has been referenced in:

  • He J & Bazan HE Epidermal growth factor synergism with TGF-beta1 via PI-3 kinase activity in corneal keratocyte differentiation. Invest Ophthalmol Vis Sci 49:2936-45 (2008).Read more (PubMed: 18579759) »
  • Behera MAet al. Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline. Reprod Sci 14:63-76 (2007).Read more (PubMed: 18089612) »

See all 2 publications for this product

Publishing research using ab23420? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"