Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-Thyroglobulin antibody - Carboxyterminal end
See all Thyroglobulin products (20) ...
Description
Rabbit polyclonal to Thyroglobulin - Carboxyterminal end
Tested applications
WB, ELISAmore details
Cross reactivity
Reacts with
Recombinant Fragment
Predicted to work with
Mouse
Immunogen
Synthetic peptide corresponding to C-terminal residues of mouse Thyroglobulin.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Globulins
Signal Transduction >> Growth Factors/Hormones >> Hormones
Applications
Show applications key
Our Abpromise guarantee covers the use of ab56192 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use a concentration of 1 µg/mlPredicted molecular weight: 305 kDa.(for 2 hours. This antibody has been tested in Western blot against the recombinant peptide used as an immunogen. We have no data on detection of endogenous protein.)
ELISA: Use at an assay dependent dilution.
Target
Function
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Tissue specificity
Thyroid gland specific.
Involvement in disease
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
Post-translational
modifications
Sulfated tyrosines are desulfated during iodination.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01266
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
Database links
- Entrez Gene: 21819 Mouse
- SwissProt: O08710 Mouse
- Unigene: 441333 Mouse
References for Anti-Thyroglobulin antibody - Carboxyterminal end (ab56192)
ab56192 has not yet been referenced specifically in any publications.
Publishing research using ab56192? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"