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Anti-Thyroglobulin antibody [DAK-Tg6] (ab16860)

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Overview

Product name

Anti-Thyroglobulin antibody [DAK-Tg6]
See all Thyroglobulin products (20) ...

Description

Mouse monoclonal [DAK-Tg6] to Thyroglobulin

Specificity

Stains cells in normal, hyperplastic and neoplastic thyroid.

Tested applications

IHC-P, WBmore details

Cross reactivity

Reacts with

Human

Immunogen

Full length protein (Human).

Positive control

Thyroid

Properties

Form

Liquid

Storage instructions

Store at +4°C.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 1% BSA, Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

DAK-Tg6

Isotype

IgG2a

Light chain type

kappa

Research areas

Cancer >> Tumor biomarkers >> Globulins
Signal Transduction >> Growth Factors/Hormones >> Hormones

Applications

Show applications key

Our Abpromise guarantee covers the use of ab16860 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     

  • WB

     

Application notes

IHC-P: 1/25 - 1/50 in an ABC method.
WB: Use at an assay dependent dilution. Detects a band of approximately 300 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Tissue specificity

Thyroid gland specific.

Involvement in disease

Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.

Sequence similarities

Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.

Post-translational
modifications

Sulfated tyrosines are desulfated during iodination.

Cellular localization

Secreted.

Target information above from: UniProt accessionP01266 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AITD 3 antibody
  • AITD3 antibody
  • hTG antibody
  • TDH3 antibody
  • TG antibody
  • Tgn antibody
  • THYG_HUMAN antibody
  • Thyroglobulin antibody
see all

Database links

References for Anti-Thyroglobulin antibody [DAK-Tg6] (ab16860)

ab16860 has not yet been referenced specifically in any publications.

Publishing research using ab16860? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"