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Products:Signal Transduction >> Growth Factors/Hormones >> Hormones
Overview
Product name
Anti-Thyroglobulin antibody
See all Thyroglobulin products (20) ...
Description
Rabbit polyclonal to Thyroglobulin
Tested applications
Enzyme Immunoassay, RIA, IP, WBmore details
Cross reactivity
Reacts with
Human
Immunogen
Full length native protein (purified from plasma) (Human)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 50% Glycerol, PBS, pH 7.5
Concentration
Concentration information loading...
Purity
Protein G purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Tumor biomarkers >> Globulins
Signal Transduction >> Growth Factors/Hormones >> Hormones
-
Western blot
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab48628 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
EIA: Use at an assay dependent dilution.
RIA: Use at an assay dependent dilution.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 307 kDa.
Target
Function
Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).
Tissue specificity
Thyroid gland specific.
Involvement in disease
Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases.
Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection.
Sequence similarities
Belongs to the type-B carboxylesterase/lipase family.
Contains 11 thyroglobulin type-1 domains.
Post-translational
modifications
Sulfated tyrosines are desulfated during iodination.
Cellular localization
Secreted.
Target information above from: UniProt accessionP01266
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AITD 3 antibody
- AITD3 antibody
- hTG antibody
see all
Database links
- Entrez Gene: 7038 Human
- Omim: 188450 Human
- SwissProt: P01266 Human
- Unigene: 654591 Human
Anti-Thyroglobulin antibody images:
Western blot
Anti-Thyroglobulin antibody (ab48628) at 5 µg/ml + Thyroglobulin protein (ab96518) at 0.01 µg
Secondary
Goat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed (ab97080) at 1/5000 dilution
developed using the ECL technique
Performed under reducing conditions.
Exposure time : 10 seconds
References for Anti-Thyroglobulin antibody (ab48628)
ab48628 has not yet been referenced specifically in any publications.
Publishing research using ab48628? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"