Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)

Overview

• Product nameAnti-Thyroid Hormone Receptor alpha 1+2 antibodySee all Thyroid Hormone Receptor alpha 1+2 primary antibodies ...
• Description
  Rabbit polyclonal to Thyroid Hormone Receptor alpha 1+2
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Dog
• Immunogen

  Synthetic peptide corresponding to a region within internal sequence amino acids 246-295 of Human Thyroid Hormone Receptor alpha 1+2 (DQIILLKGCC MEIMSLRAAV RYDPESDTLT LSGEMAVKRE QLKNGGLGVV).

  Run BLAST with Run BLAST with
• Positive controlJurkat cell lysate

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: 2% Sucrose, PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Signal transduction
  • Nuclear signaling
  • Nuclear hormone receptors
  • Retanoic and retanoid

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Signal Transduction
  • Signaling Pathway
  • Nuclear Signaling
  • Nuclear Hormone Receptors
  • Retinoic & Retinoid

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Retinoic & Retinoid

  • Neuroscience
  • Endocrine system
  • Thyroid axis

Applications

Target

• FunctionNuclear hormone receptor. High affinity receptor for triiodothyronine.
• Involvement in diseaseDefects in THRA are the cause of congenital hypothyroidism non-goitrous type 6 (CHNG6) [MIM:614450]. A disease characterized by growth retardation, developmental retardation, skeletal dysplasia, borderline low thyroxine levels and high triiodothyronine levels. There is differential sensitivity to thyroid hormone action, with retention of hormone responsiveness in the hypothalamic pituitary axis and liver but skeletal, gastrointestinal, and myocardial resistance.
• Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
  Contains 1 nuclear receptor DNA-binding domain.
• DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
• Cellular localizationNucleus.

Target information above from: UniProt accession P10827 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 403601 Dog
  • Entrez Gene: 7067 Human
  • Entrez Gene: 21833 Mouse
  • Entrez Gene: 81812 Rat
  • Omim: 190120 Human
  • SwissProt: E2QZW9 Dog
  • SwissProt: P10827 Human
  • SwissProt: P63058 Mouse

  • SwissProt: P63059 Rat
  • Unigene: 724 Human
  • Unigene: 265917 Mouse
  • Unigene: 442648 Mouse
  • Unigene: 11307 Rat

  see all

• Alternative names
  c-erbA-1 antibodyC-erbA-alpha antibodyEAR-7 antibody

  ERBA 1 antibodyERBA antibodyERBA related 7 antibodyNuclear receptor subfamily 1 group A member 1 antibodyTHA_HUMAN antibodyTHRA antibodyThra1 antibodyThra2 antibodyThyroid hormone receptor alpha 1 antibodyThyroid hormone receptor alpha 2 antibodyThyroid hormone receptor alpha antibodyTR alpha 1 antibodyTR alpha 2 antibodyTra1 antibodyTriiodothyronine receptor antibodyV-erbA-related protein 7 antibody

  see all

Anti-Thyroid Hormone Receptor alpha 1+2 antibody images

• 

  Western blot - Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)
  Anti-Thyroid Hormone Receptor alpha 1+2 antibody (ab105003) at 0.5 µg/ml + Jurkat cell lysate at 10 µg
  
  Predicted band size : 55 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Thyroid Hormone Receptor alpha 1+2 antibody (ab105003)
  ab105003, at 4µg/ml, staining Thyroid Hormone Receptor alpha 1 + 2, in Human squamous epithelial cells by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Magnification 400x.