Anti-Thyroid Hormone Receptor antibody (ab63962)

Overview

  • Product nameAnti-Thyroid Hormone Receptor antibody
    See all Thyroid Hormone Receptor primary antibodies
  • Description
    Goat polyclonal to Thyroid Hormone Receptor
  • Specificityab63962 is expected to recognize both reported isoforms of Thyroid Hormone Receptor alpha (THRA) (NP_955366.1; NP_003241.2). This antibody is not expected to cross-react to Thyroid Hormone Receptor beta (THRB).
  • Tested applicationsWB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Sheep, Cow, Dog, Pig
  • Immunogen

    Synthetic peptide:

    C-KEEMIRSLQQRP

    , corresponding to internal sequence amino acids 147-158 of Human Thyroid Hormone Receptor

  • Positive control
    • Human Bone Marrow lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab63962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
ELISA
  • Application notesPeptide ELISA: antibody detection limit dilution 1:32/000.
    WB: Use at a concentration of 0.5 - 1.5 µg/ml. Detects bands of approximately 60 and 50 kDa (predicted molecular weights: 54 and 47 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceThyroid hormone receptors (TRs) are ligand dependent members of the steroid/retinoic acid superfamily of transcription factors. The two genes encoding TRs identified to date, TR alpha and TR beta, have been mapped to human chromosomes 17 and 3, respectively. TRs bind to thyroid hormone response elements (TREs) with half site binding motifs in the orientation of palindromes, direct repeats, or inverted palindromes. The affinities of binding are both variable and influenced differentially by 3,5,3 triiodo L thyronine (T3). Thyroid hormones, through their interaction with the TR affect metabolic processes, growth and development.
    • Cellular localizationNuclear
    • Database links
    • Alternative names
      • ERBA ALPHA antibody
      • ERBA beta antibody
      • ERBA1 antibody
      • ERBA2 antibody
      • NR1A1 antibody
      • NR1A2 antibody
      • THR1 antibody
      • THRA antibody
      • THRA1 antibody
      • THRA2 antibody
      • THRB antibody
      • THRB1 antibody
      • THRB2 antibody
      • Thyroid hormone receptor alpha antibody
      • Thyroid hormone receptor beta antibody
      see all

    Anti-Thyroid Hormone Receptor antibody images

    References for Anti-Thyroid Hormone Receptor antibody (ab63962)

    ab63962 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"