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Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417)

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Overview

  • Product nameAnti-Thyroid Hormone Receptor beta antibody - ChIP GradeSee all Thyroid Hormone Receptor beta primary antibodies ...
  • Description
    Rabbit polyclonal to Thyroid Hormone Receptor beta - ChIP Grade
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide corresponding to a region within N terminal amino acids 1-50 (MNYCMPEVHE VCPAASSNCY MQVTDYLAYL EDSPALSGRD VQAVPSSSIY) of Mouse Thyroid Hormone (NP_033406; UniProt ID: P10828 isoform 2).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlMouse muscle lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab104417 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 1 µg/ml. Predicted molecular weight: 2, 54 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionHigh affinity receptor for triiodothyronine.
  • Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P10828 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibodyC ERBA 2 antibodyC ERBA BETA antibody
        c-erbA-2 antibodyc-erbA-beta antibodyERBA 2 antibodyERBA BETA antibodyERBA2 antibodyErythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibodygeneralized resistance to thyroid hormone antibodyGRTH antibodyMGC126109 antibodyMGC126110 antibodyNR1A2 antibodyNuclear receptor subfamily 1 group A member 2 antibodyOncogene ERBA2 antibodyPRTH antibodyTHB_HUMAN antibodyTHR1 antibodyTHRB 1 antibodyTHRB 2 antibodyTHRB antibodyTHRB1 antibodyTHRB2 antibodyThyroid hormone nuclear receptor beta variant 1 antibodyThyroid hormone receptor beta 1 antibodyThyroid hormone receptor beta 2 antibodyThyroid hormone receptor beta antibodyThyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
      see all

    Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade images

    • Western blot - Thyroid Hormone Receptor beta antibody (ab104417)
      Western blot - Thyroid Hormone Receptor beta antibody (ab104417)
      Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417) at 1 µg/ml + Mouse muscle lysate at 10 µg

      Predicted band size : 2, 54 kDa
    • ChIP - Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417)
      ChIP - Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417)

      Application: ChIP
      Sample Type      : mouse liver tissue
      Chromatin Used: 100ug tissue
      Antibody Used: 10ug  
      P = Positive genomic loci 1-3

    References for Anti-Thyroid Hormone Receptor beta antibody - ChIP Grade (ab104417)

    ab104417 has not yet been referenced specifically in any publications.

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