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Anti-Thyroid Hormone Receptor beta antibody (ab106813)

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Overview

  • Product nameAnti-Thyroid Hormone Receptor beta antibodySee all Thyroid Hormone Receptor beta primary antibodies ...
  • Description
    Goat polyclonal to Thyroid Hormone Receptor beta
  • Specificityab106813 is not expected to cross-react to THRA.
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Chicken, Dog, Pig
  • Immunogen

    Synthetic peptide: C-REELQKSIGHKP, corresponding to internal sequence amino acids 201-212 of Human Thyroid Hormone Receptor beta (NP_000452.2).

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive controlHuman Bone Marrow lysate

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferPreservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab106813 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality Polyclonal
  • IsotypeIgG
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab106813 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: Isoform Beta 1, 53 ; Isoform Beta 2, 54 kDa.

Target

  • FunctionHigh affinity receptor for triiodothyronine.
  • Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P10828 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibodyC ERBA 2 antibodyC ERBA BETA antibody
      c-erbA-2 antibodyc-erbA-beta antibodyERBA 2 antibodyERBA BETA antibodyERBA2 antibodyErythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibodygeneralized resistance to thyroid hormone antibodyGRTH antibodyMGC126109 antibodyMGC126110 antibodyNR1A2 antibodyNuclear receptor subfamily 1 group A member 2 antibodyOncogene ERBA2 antibodyPRTH antibodyTHB_HUMAN antibodyTHR1 antibodyTHRB 1 antibodyTHRB 2 antibodythrB antibodyTHRB1 antibodyTHRB2 antibodyThyroid hormone nuclear receptor beta variant 1 antibodyThyroid hormone receptor beta 1 antibodyThyroid hormone receptor beta 2 antibodyThyroid hormone receptor beta antibodyThyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
    see all

Anti-Thyroid Hormone Receptor beta antibody images

  • Western blot - Thyroid Hormone Receptor beta antibody (ab106813)
    Western blot - Thyroid Hormone Receptor beta antibody (ab106813)
    Anti-Thyroid Hormone Receptor beta antibody (ab106813) at 0.3 µg/ml + Human Bone Marrow lysate (in RIPA buffer) at 35 µg
    developed using the ECL technique

    Predicted band size : Isoform Beta 1, 53 ; Isoform Beta 2, 54 kDa

References for Anti-Thyroid Hormone Receptor beta antibody (ab106813)

ab106813 has not yet been referenced specifically in any publications.

Publishing research using ab106813 ? Please let us know so that we can cite the reference in this datasheet

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Customer called because they had been attempting to use our products ab5622 and ab106813 in WB on human and rat cell lines but had experiences NSB.  They attempted many troubleshooting steps but  were unable to resolve the issue. They have found another p...

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Thank you for contacting us. Your credit note IDs are XXX. I am sorry that this antibody did not perform as stated on the datasheet. If payment has already been made on the original order and you wish to receive a refund, please ask your purcha...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"