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Anti-Thyroid Hormone Receptor beta antibody (ab15545)

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Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab15545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
IHC-P IHC-P: 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • FunctionHigh affinity receptor for triiodothyronine.
  • Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
    Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • Cellular localizationNucleus.

    • Target information above from: UniProt accession P10828 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibodyC ERBA 2 antibodyC ERBA BETA antibody
        c-erbA-2 antibodyc-erbA-beta antibodyERBA 2 antibodyERBA 2 antibodyERBA BETA antibodyERBA BETA antibodyERBA2 antibodyERBA2 antibodyErythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibodygeneralized resistance to thyroid hormone antibodyGRTH antibodyGRTH antibodyMGC126109 antibodyMGC126110 antibodyNR1A2 antibodyNuclear receptor subfamily 1 group A member 2 antibodyOncogene ERBA2 antibodyPRTH antibodyTHB_HUMAN antibodyTHR 1 antibodyTHR1 antibodyTHRB 1 antibodyTHRB 2 antibodyTHRB antibodyTHRB antibodyTHRB1 antibodyTHRB2 antibodyThyroid hormone nuclear receptor beta variant 1 antibodyThyroid hormone receptor beta 1 antibodyThyroid hormone receptor beta 2 antibodyThyroid hormone receptor beta antibodyThyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
      see all

    Anti-Thyroid Hormone Receptor beta antibody images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (ab15545)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody (ab15545)
      Colon carcinoma stained with ab15545

    References for Anti-Thyroid Hormone Receptor beta antibody (ab15545)

    ab15545 has not yet been referenced specifically in any publications.

    Publishing research using ab15545 ? Please let us know so that we can cite the reference in this datasheet

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    I just left a voice message with technical service. Below is the specific question that I have. There are several TR alpha and TR beta specific antibodies that you sell. I was wondering if you also sell the peptides for them. The catalog numbers of th...

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    Thank you for your enquiry. Unfortunately, we don't have the corresponding peptides for these antibodies. If you cannot find what you are looking for within the Abcam catalogue, you can click on the link to "The World's Antibody Gateway". The World's A...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"