Anti-Thyroid Hormone Receptor beta antibody (ab5622)
- Product nameAnti-Thyroid Hormone Receptor beta antibodySee all Thyroid Hormone Receptor beta primary antibodies ...
- DescriptionRabbit polyclonal to Thyroid Hormone Receptor beta
- SpecificityThis antibody does not detect TR alpha-1 or TRv alpha-2.
- Tested applicationsGel supershift assays, ICC, WB more details
- Species reactivityReacts with: Rat, Human
Synthetic peptide: CIFHLDHDDVNDQSVSSAQTF, corresponding to amino acids 62-82 of Human Thyroid Hormone Receptor (beta). This sequence is completely conserved between human and rat TR beta-1.
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.05% Sodium Azide
- PurityWhole antiserum
- Clonality Polyclonal
- Research Areas
Our Abpromise guarantee covers the use of ab5622 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|Gel supershift assays|
WB: 1/200. Detects a band of approximately 55 kDa (predicted molecular weight: 42 kDa) representing recombinant human TRv beta-1 expressed in E. coli.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
- FunctionHigh affinity receptor for triiodothyronine.
- Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
- Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
- DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
- Cellular localizationNucleus.
- Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibodyC ERBA 2 antibodyC ERBA BETA antibody
- c-erbA-2 antibodyc-erbA-beta antibodyERBA 2 antibodyERBA BETA antibodyERBA2 antibodyErythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibodygeneralized resistance to thyroid hormone antibodyGRTH antibodyMGC126109 antibodyMGC126110 antibodyNR1A2 antibodyNuclear receptor subfamily 1 group A member 2 antibodyOncogene ERBA2 antibodyPRTH antibodyTHB_HUMAN antibodyTHR 1 antibodyTHR1 antibodyTHRB 1 antibodyTHRB 2 antibodyTHRB antibodyTHRB1 antibodyTHRB2 antibodyThyroid hormone nuclear receptor beta variant 1 antibodyThyroid hormone receptor beta 1 antibodyThyroid hormone receptor beta 2 antibodyThyroid hormone receptor beta antibodyThyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody
References for Anti-Thyroid Hormone Receptor beta antibody (ab5622)
This product has been referenced in:
- Modesti PA et al. Reduced expression of thyroid hormone receptors and beta-adrenergic receptors in human failing cardiomyocytes. Biochem Pharmacol 75:900-6 (2008). Read more (PubMed: 18031713) »
- Sun Y et al. Liver proteome analysis of adaptive response in rat immediately after partial hepatectomy. Proteomics 7:4398-407 (2007). Read more (PubMed: 17979177) »