Anti-Thyroid Hormone Receptor beta antibody, prediluted (ab15546)

Overview

• Product nameAnti-Thyroid Hormone Receptor beta antibody, predilutedSee all Thyroid Hormone Receptor beta primary antibodies ...
• Description
  Rabbit polyclonal to Thyroid Hormone Receptor beta, prediluted
• Tested applicationsIHC-P more details
• Species reactivity
  Reacts with: Human
  Predicted to work with: Mouse, Rat, Sheep, Dog
• Immunogen

  Synthetic peptide: GMSEACLHRKSHSERRSTLK , corresponding to amino acids 31-50 of Human Thyroid Hormone Receptor beta.

  Run BLAST with Run BLAST with
• Positive controlColon carcinoma.

Properties

• FormPrediluted
• Storage instructionsStore at +4°C.
• Storage bufferPreservative: 0.1% Sodium Azide
  Constituents: 1% BSA, 50mM Tris, pH 7.6
• Concentration information loading...
• PurityImmunogen affinity purified
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Neuroscience
  • Endocrine system
  • Thyroid axis

Applications

Target

• FunctionHigh affinity receptor for triiodothyronine.
• Involvement in diseaseDefects in THRB are the cause of generalized thyroid hormone resistance (GTHR) [MIM:188570, 274300]. GTHR is transmitted as an autosomal dominant trait, but an autosomal recessive form also exists. The disease is characterized by goiter, abnormal mental functions, increased susceptibility to infections, abnormal growth and bone maturation, tachycardia and deafness. Affected individuals may also have attention deficit-hyperactivity disorders (ADHD) and language difficulties. GTHR patients also have high levels of circulating thyroid hormones (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH).
  Defects in THRB are the cause of selective pituitary thyroid hormone resistance (PRTH) [MIM:145650]; also known as familial hyperthyroidism due to inappropriate thyrotropin secretion. PRTH is a variant form of thyroid hormone resistance and is characterized by clinical hyperthyroidism, with elevated free thyroid hormones, but inappropriately normal serum TSH. Unlike GRTH, where the syndrome usually segregates with a dominant allele, the mode of inheritance in PRTH has not been established.
• Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
  Contains 1 nuclear receptor DNA-binding domain.
• DomainComposed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
• Cellular localizationNucleus.

Target information above from: UniProt accession P10828 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 403599 Dog
  • Entrez Gene: 7068 Human
  • Entrez Gene: 21834 Mouse
  • Entrez Gene: 24831 Rat
  • Omim: 190160 Human
  • SwissProt: P10828 Human
  • SwissProt: P37242 Mouse
  • SwissProt: P18113 Rat

  • SwissProt: Q28571 Sheep
  • Unigene: 187861 Human
  • Unigene: 728126 Human
  • Unigene: 32563 Mouse
  • Unigene: 88692 Rat

  see all

• Alternative names
  Avian erythroblastic leukemia viral (v erb a) oncogene homolog 2 antibodyC ERBA 2 antibodyC ERBA BETA antibody

  c-erbA-2 antibodyc-erbA-beta antibodyERBA 2 antibodyERBA BETA antibodyERBA2 antibodyErythroblastic leukemia viral (v erb a) oncogene homolog 2 avian antibodygeneralized resistance to thyroid hormone antibodyGRTH antibodyMGC126109 antibodyMGC126110 antibodyNR1A2 antibodyNuclear receptor subfamily 1 group A member 2 antibodyOncogene ERBA2 antibodyPRTH antibodyTHB_HUMAN antibodyTHR 1 antibodyTHR1 antibodyTHRB 1 antibodyTHRB 2 antibodyTHRB antibodyTHRB1 antibodyTHRB2 antibodyThyroid hormone nuclear receptor beta variant 1 antibodyThyroid hormone receptor beta 1 antibodyThyroid hormone receptor beta 2 antibodyThyroid hormone receptor beta antibodyThyroid hormone receptor, beta (erythroblastic leukemia viral (v erb a) oncogene homolog 2, avian) antibody

  see all

Anti-Thyroid Hormone Receptor beta antibody, prediluted images

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  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Thyroid Hormone Receptor beta antibody, prediluted (ab15546)
  ab15546 staining Thyroid Hormone Receptor beta in colon carcinoma by Immunohistochemistry (FFPE-sections).