Anti-Thyroid Peroxidase antibody (ab126889)

Overview

• Product nameAnti-Thyroid Peroxidase antibodySee all Thyroid Peroxidase primary antibodies ...
• Description
  Goat polyclonal to Thyroid Peroxidase
• Specificityab126889 is expected to recognize reported isoforms a (NP_000538.3) and e (NP_783653.1).
• Tested applicationsWB more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide: C-TRHVIQVSNEVVTDD with a Cysteine residue linker, corresponding to internal sequence amino acids 209-223 of Human Thyroid Peroxidase (NP_000538.3; NP_783650.1; NP_783652.1; NP_783653.1).

  Run BLAST with Run BLAST with
• Positive controlHuman thyroid gland lysate.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Storage bufferpH: 7.30
  Preservative: 0.02% Sodium azide
  Constituents: 99% Tris buffered saline, 0.5% BSA
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesPurified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Metabolism
  • Types of disease
  • Cancer

  • Metabolism
  • Pathways and Processes
  • Endocrine metabolism
  • Hormone biosynthesis

  • Metabolism
  • Pathways and Processes
  • Redox metabolism
  • Antioxidants

  • Cancer
  • Cancer Metabolism
  • Metabolic signaling pathway
  • Hormone biosynthesis

  • Cancer
  • Cancer Metabolism
  • Cellular metabolic process

  • Signal Transduction
  • Growth Factors/Hormones
  • Hormones

  • Neuroscience
  • Endocrine system
  • Thyroid axis

Applications

Target

• FunctionIodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
• PathwayHormone biosynthesis; thyroid hormone biosynthesis.
• Involvement in diseaseNote=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.
  Defects in TPO are the cause of congenital hypothyroidism due to dyshormonogenesis type 2A (CHDH2A) [MIM:274500]; also called genetic defect in thyroid hormonogenesis 2A or thyroid hormone organification defect II. CHDH2A is due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete.
• Sequence similaritiesBelongs to the peroxidase family. XPO subfamily.
  Contains 1 EGF-like domain.
  Contains 1 Sushi (CCP/SCR) domain.
• Post-translational
  modificationsGlycosylated.
  Heme is covalently bound through a H(2)O(2)-dependent autocatalytic process. Heme insertion is important for the delivery of protein at the cell surface.
  Cleaved in its N-terminal part.
• Cellular localizationMembrane and Cell surface.

Target information above from: UniProt accession P07202 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 7173 Human
  • Omim: 606765 Human
  • SwissProt: P07202 Human
  • Unigene: 467554 Human

• Alternative names
  MSA antibodyPERT_HUMAN antibodyTDH2A antibody

  Thyroid microsomal antigen antibodyThyroid peroxidase antibodyThyroperoxidase antibodyTPO antibodyTPX antibody

  see all

Anti-Thyroid Peroxidase antibody images

• 

  Western blot - Anti-Thyroid Peroxidase antibody (ab126889)
  Anti-Thyroid Peroxidase antibody (ab126889) at 0.3 µg/ml + Human thyroid gland lysate (in RIPA buffer) at 35 µg
  developed using the ECL technique
  
  Predicted band size : 103 kDa