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Tick-Borne Encephalitis Virus E protein (ab68368)

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Overview

  • Product nameTick-Borne Encephalitis Virus E proteinSee all Tick-Borne Encephalitis Virus E proteins and peptides ...
  • Protein descriptionRecombinant fragment, corresponding to amino acids 95-229 of Tick-Borne Encephalitis Virus glycoprotein E.
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesThis protein was purified by proprietary chromatographic techniques. Encephalitis protein is >95% pure as determined by 10% PAGE (coomassie staining).
  • Biological activityThis protein is immunoreactive with sera of encephalitis virus infected individuals.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 0.05% Tween 20, 8M Urea, 200mM Sodium chloride, 20mM MES, pH 6.5
  • Concentration information loading...
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab68368 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent dilution. Predicted molecular weight: 16 kDa.
    ELISA ELISA: Use at an assay dependent dilution.

    Protein info

    • Alternative names
        TBEV gE
  • RelevanceTBE is caused by the tick-borne encephalitis virus (TBEV), a member of the family Flaviviridae. Flaviviruses consist of three structural proteins: the core nucleocapsid protein C, and the envelope glycoproteins M and E. Glycoprotein E is a class II viral fusion protein that mediates both receptor binding and fusion. Class II viral fusion proteins are found in flaviviruses and alphaviruses, and are structurally distinct from class I fusion proteins from influenza virus and HIV. Glycoprotein E is comprised of three domains: domain I (dimerisation domain) is an 8-stranded beta barrel, domain II (central domain) is an elongated domain composed of twelve beta strands and two alpha helices, and domain III (immunoglobulin-like domain) is an IgC-like module with ten beta strands. Tick Borne Encephalitis is a viral disease spread via the bite of an infected Ixodes tick and can also be transmitted via unpasturised milk from infected goats or cows. Ticks bite humans when they walk through undergrowth or grasses where contact is made. It is most prevalent in Europe and Asia.
  • Cellular localizationCell membrane

    • References for Tick-Borne Encephalitis Virus E protein (ab68368)

    ab68368 has not yet been referenced specifically in any publications.

    Publishing research using ab68368 ? Please let us know so that we can cite the reference in this datasheet

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    We are inquiring for purified viral antigens to be used in ELISA for human sera.

    There are two products for tick-borne encephalitis virus that were found here:

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    ab43031 peptide is a region within amino acids 296-414 from conserved sequences derived from the Sophyin and syberian strains. Unfortunately we cannot disclose the exact sequences used. Similarly for ab68368 we can not disclose any further infor...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"