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Anti-Tollip antibody [Kimmy-2] (ab16089)

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Overview

Product name

Anti-Tollip antibody [Kimmy-2]
See all Tollip products (7) ...

Description

Mouse monoclonal [Kimmy-2] to Tollip

Tested applications

IHC-P, WB, IPmore details

Cross reactivity

Reacts with

Mouse, Human

Immunogen

Recombinant fragment, corresponding to amino acids 1 - 247 of Mouse Tollip.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.02% Sodium Azide
Constituents: PBS

Concentration

Concentration information loading...

Purity

>95% by SDS-PAGE

Purification notes

Purified from concentrated hybridoma tissue supernatant.

Clonality

Monoclonal

Clone number

Kimmy-2

Isotype

IgG1

Research areas

Immunology >> Innate Immunity >> TLR Signaling
Immunology >> Innate Immunity >> Cytokines >> Interleukins
Immunology >> Immunoglobulins >> Receptors

Applications

Show applications key

Our Abpromise guarantee covers the use of ab16089 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     

  • WB

     

  • IP

     

Application notes

IHC-P: Use at an assay dependent dilution. Perform heat mediated antigen retrieval before commencing with IHC staining protocol PMID 17855441.
IP: Use at an assay dependent dilution.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 33 kDa.


Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.

Sequence similarities

Belongs to the tollip family.
Contains 1 C2 domain.
Contains 1 CUE domain.

Post-translational
modifications

Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.

Cellular localization

Cytoplasm.

Target information above from: UniProt accessionQ9H0E2 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Adapter protein antibody
  • FLJ33531 antibody
  • IL 1RAcPIP antibody
  • IL1RAcPIP antibody
  • TOLIP antibody
  • TOLIP_HUMAN antibody
  • Toll interacting protein antibody
  • Toll-interacting protein antibody
  • tollip antibody
see all

Database links

References for Anti-Tollip antibody [Kimmy-2] (ab16089)

This product has been referenced in:

  • Chen Y  et al. Differential expression of novel tyrosine kinase substrates during breast cancer development. Mol Cell Proteomics 6:2072-87 (2007). IHC-P; Human.Read more (PubMed: 17855441) »

See 1 publication for this product

Publishing research using ab16089? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"